Mitsis Effie M, Cosgrove Kelly P, Staley Julie K, Frohlich Erin B, Bois Frederic, Tamagnan Gilles D, Estok Kristina M, Seibyl John P, Van Dyck Christopher H
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA.
Ann N Y Acad Sci. 2007 Feb;1097:168-70. doi: 10.1196/annals.1379.015.
Human postmortem studies have reported decreases with age in high-affinity nicotine binding in brain. We have been investigating in vivo the availability of the beta(2)-containing nicotinic acetylcholine receptor (beta(2)-nAChR) in healthy nonsmokers (18-85 years of age) using [(123)I]5-IA-85380 SPECT imaging. Age and regional beta(2)-nAChR availability (V(T)(,)) have been observed to be inversely correlated in all brain regions analyzed, with decline ranging from 21% (cerebellum) to 36% (thalamus), or by up to 5% per decade of life. Preliminary results have confirmed postmortem reports of age-related decline in high-affinity nicotine binding with age and may elucidate the role of beta(2)-nAChRs in the cognitive decline associated with aging.
人体尸检研究报告称，大脑中高亲和力尼古丁结合随年龄增长而减少。我们一直在使用[123I]5-IA-85380单光子发射计算机断层扫描（SPECT）成像技术，对18至85岁的健康非吸烟者体内含β2的烟碱型乙酰胆碱受体（β2-nAChR）的可用性进行研究。在所有分析的脑区中，年龄与区域β2-nAChR可用性（V T）呈负相关，下降幅度从21%（小脑）到36%（丘脑），即每十年高达5%。初步结果证实了尸检报告中高亲和力尼古丁结合随年龄增长而下降的情况，并可能阐明β2-nAChR在与衰老相关的认知衰退中的作用。
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