Roy M M
Neuroscience Training Program, University of Wisconsin-Madison.
Physiol Behav. 1992 Jan;51(1):105-9. doi: 10.1016/0031-9384(92)90210-s.
Most sexual dimorphisms in reproductive behavior are hormonally organized in the guinea pig. The study sought to determine whether the sexually dimorphic requirement for the aromatization of testosterone in the activation of mounting is organized by testosterone prenatally and whether aromatization of testosterone contributes to the organization of mounting behavior. Pregnant females were treated with testosterone, the aromatase inhibitor ATD, or vehicle from days 28-65 of gestation. The offspring were gonadectomized and tested as adults for lordosis and androgen-activated mounting behavior. Prenatal testosterone treatments altered the hormonal requirements for androgen-activated mounting in females such that they resembled normal males, and did not require aromatization as adults. Prenatal inhibition of aromatase activity decreased mounting activity in females but not in males. This treatment had no influence on lordosis in either sex. The results support the hypothesis that the same hormones that activate mounting behavior in the adult guinea pig are responsible for the organization of mounting behavior.
豚鼠生殖行为中的大多数性别二态性是由激素组织调控的。该研究旨在确定在雄性性行为激活过程中，睾酮芳香化的性别二态性需求是否在产前由睾酮组织形成，以及睾酮的芳香化是否有助于雄性性行为的组织形成。在妊娠第28至65天，对怀孕的雌性豚鼠分别给予睾酮、芳香化酶抑制剂ATD或赋形剂。后代在成年后进行性腺切除，并测试其是否有脊柱前凸和雄激素激活的雄性性行为。产前睾酮处理改变了雌性豚鼠雄激素激活的雄性性行为的激素需求，使其类似于正常雄性，成年后不需要芳香化。产前抑制芳香化酶活性会降低雌性豚鼠的雄性性行为活性，但对雄性豚鼠没有影响。这种处理对两性的脊柱前凸均无影响。结果支持了这样一种假设，即激活成年豚鼠雄性性行为的相同激素负责雄性性行为的组织形成。
