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一种用于测定茶苯海明及其有关物质的简单高效液相色谱 - 紫外检测法——一种未知杂质的鉴定

A simple HPLC-UV method for the determination of dimenhydrinate and related substances--dentification of an unknown impurity.

作者信息

Döge U, Eger K

机构信息

Institute for Pharmacy, Pharmaceutical Chemistry, University of Leipzig, Germany.

出版信息

Pharmazie. 2007 Mar;62(3):174-8.

PMID:17416192
Abstract

During the revision of the dimenhydrinate monograph of the European Pharmacopoeia a HPLC-UV method was developed. The procedure described allows a qualitative and quantitative determination of both dimenhydrinate compounds and of thirteen related substances. Furthermore a hitherto unknown impurity was identified and integrated into the purity check. Also 18 samples of dimenhydrinate have been tested. Thereby the relevant impurities of dimenhydrinate could be nominated and quantified.

摘要

在修订欧洲药典中茶苯海明专论时，开发了一种高效液相色谱 - 紫外检测法。所述方法可对茶苯海明化合物及其13种相关物质进行定性和定量测定。此外，还鉴定出一种此前未知的杂质并纳入纯度检查。同时对18个茶苯海明样品进行了检测，从而可以对茶苯海明的相关杂质进行命名和定量。

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