Ashton-Miller James A, DeLancey John O L
Department of Mechanical Engineering, Biomechanics Engineering and Institute of Gerontology, G.G. Brown 3208, University of Michigan, Ann Arbor, MI 48109-2125, USA.
Ann N Y Acad Sci. 2007 Apr;1101:266-96. doi: 10.1196/annals.1389.034. Epub 2007 Apr 7.
The anatomic structures in the female that prevent incontinence and genital organ prolapse on increases in abdominal pressure during daily activities include sphincteric and supportive systems. In the urethra, the action of the vesical neck and urethral sphincteric mechanisms maintains urethral closure pressure above bladder pressure. Decreases in the number of striated muscle fibers of the sphincter occur with age and parity. A supportive hammock under the urethra and vesical neck provides a firm backstop against which the urethra is compressed during increases in abdominal pressure to maintain urethral closure pressures above the rapidly increasing bladder pressure. This supporting layer consists of the anterior vaginal wall and the connective tissue that attaches it to the pelvic bones through the pubovaginal portion of the levator ani muscle, and the uterosacral and cardinal ligaments comprising the tendinous arch of the pelvic fascia. At rest the levator ani maintains closure of the urogenital hiatus. They are additionally recruited to maintain hiatal closure in the face of inertial loads related to visceral accelerations as well as abdominal pressurization in daily activities involving recruitment of the abdominal wall musculature and diaphragm. Vaginal birth is associated with an increased risk of levator ani defects, as well as genital organ prolapse and urinary incontinence. Computer models indicate that vaginal birth places the levator ani under tissue stretch ratios of up to 3.3 and the pudendal nerve under strains of up to 33%, respectively. Research is needed to better identify the pathomechanics of these conditions.
女性体内在日常活动中腹部压力增加时防止尿失禁和生殖器官脱垂的解剖结构包括括约肌系统和支持系统。在尿道,膀胱颈和尿道括约肌机制的作用使尿道闭合压维持在膀胱压之上。随着年龄增长和经产次数增加,括约肌的横纹肌纤维数量会减少。尿道和膀胱颈下方的支持性吊床在腹部压力增加时为尿道提供坚实的支撑,使尿道受到挤压,从而维持尿道闭合压高于快速上升的膀胱压。这个支持层由阴道前壁以及通过肛提肌耻骨阴道部分将其与骨盆骨相连的结缔组织,以及构成盆筋膜腱弓的子宫骶韧带和主韧带组成。在静息状态下,肛提肌维持泌尿生殖裂孔的闭合。在涉及腹壁肌肉和膈肌收缩的日常活动中,面对与内脏加速相关的惯性负荷以及腹部加压时,肛提肌会额外收缩以维持裂孔闭合。阴道分娩与肛提肌缺陷、生殖器官脱垂和尿失禁的风险增加有关。计算机模型表明,阴道分娩时肛提肌所承受的组织拉伸率高达3.3,阴部神经所承受的应变高达33%。需要开展研究以更好地明确这些病症的发病机制。