[分化抑制因子2在骨骼肌再生中作用的研究进展]
[Research advance of role of inhibitor of differentiation 2 in skeletal muscle regeneration].
作者信息
Lai Guihua, Qiu Xiaozhong, Ouyang Jun
机构信息
Department of Anatomy, Southern Medical University, Guangdong Provincial Key Laboratory of Tissue Construction and Inspection, Guangzhou Guangdong, 510515, PR China.
出版信息
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2007 Mar;21(3):307-10.
OBJECTIVE
To review researches of the role of inhibitor of differentiation 2(Id2) in skeletal muscle regeneration.
METHODS
The latest original literature concerning Id2 and its role in skeletal muscle regeneration was extensively reviewed.
RESULTS
Id2 could form heterodimers by combining with E protein to prevent myogenic regulatory factors (MRFs) forming heterodimers by combining with E protein, to inhibit the transcription activity of MRFs and differentiation of skeletal muscle cell.
CONCLUSION
Id2 plays an important role in skeletal muscle regeneration.
目的
综述分化抑制因子2（Id2）在骨骼肌再生中作用的研究。
方法
广泛查阅有关Id2及其在骨骼肌再生中作用的最新原始文献。
结果
Id2可与E蛋白结合形成异二聚体，阻止肌源性调节因子（MRFs）与E蛋白结合形成异二聚体，抑制MRFs的转录活性及骨骼肌细胞分化。
结论
Id2在骨骼肌再生中起重要作用。
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