一例独特的仅表达IgD的脾脏边缘区淋巴瘤伴免疫球蛋白基因突变：发育起源的意义

A unique case of IgD-only splenic marginal-zone lymphoma with mutated immunoglobulin genes: ontogenetic implications.

作者信息

Papadaki Theodora, Stamatopoulos Kostas, Mavrommatis Theodore, Anagnostopoulos Achilles, Anagnostou Dimitra

机构信息

Hemopathology Department, Evangelismos Hospital, Athens, Greece.

出版信息

Leuk Res. 2008 Jan;32(1):155-7. doi: 10.1016/j.leukres.2007.03.013. Epub 2007 Apr 8.

DOI:10.1016/j.leukres.2007.03.013

PMID:17420049

Abstract

Splenic marginal zone lymphoma (SMZL) is a rare indolent lymphoma subtype which accounts for less than 1% of all non-Hodgkin's lymphomas. We here report a unique case of IgD-only SMZL with mutated immunoglobulin variable region genes and discuss possible ontogenetic derivation.

摘要

脾边缘区淋巴瘤（SMZL）是一种罕见的惰性淋巴瘤亚型，占所有非霍奇金淋巴瘤的比例不到1%。我们在此报告一例独特的仅IgD阳性的SMZL病例，其免疫球蛋白可变区基因发生突变，并讨论可能的起源。