Wei Peng, Liu Jia, Zhou Hao-Li, Han Zhi-Tong, Wu Qing-Ying, Pang Jiang-Xia, Liu Su, Wang Ting-Hua
Renmin Western Road No. 191, Institute of Neuroscience, Kunming Medical College, 650031, China.
Neurosci Lett. 2007 May 23;419(1):49-54. doi: 10.1016/j.neulet.2007.03.046. Epub 2007 Mar 25.
This study evaluated the therapeutic effect of neural stem cells (NSCs) transplanted into Parkinson's disease (PD) rats. NSCs were identified in vitro, then engrafted into the striatum of the PD rats. The rotational behavior was evaluated 1, 2, 4 and 6 weeks. A significant rotational behavior improvement was observed in PD rats subjected to cell transplantation. Transplanted NSCs not only express Nerve growth factor and Neurotrophin-3 in vitro, but also survive and partly differentiate into tyrosine hydroxylase (TH) positive cells in vivo. The results show that NSCs could be effective for PD treatment and the mechanisms might involve the neurotrophin expression and the neural differentiation.
本研究评估了将神经干细胞（NSCs）移植到帕金森病（PD）大鼠体内的治疗效果。神经干细胞在体外被鉴定，然后植入PD大鼠的纹状体。在1、2、4和6周时评估旋转行为。在接受细胞移植的PD大鼠中观察到旋转行为有显著改善。移植的神经干细胞不仅在体外表达神经生长因子和神经营养因子-3，而且在体内存活并部分分化为酪氨酸羟化酶（TH）阳性细胞。结果表明，神经干细胞对PD治疗可能有效，其机制可能涉及神经营养因子表达和神经分化。
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