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多巴胺D2受体刺激可促进成年小鼠海马体中神经祖细胞的增殖。

Dopamine D2 receptor stimulation promotes the proliferation of neural progenitor cells in adult mouse hippocampus.

作者信息

Hiramoto Takeshi, Kanda Yasunari, Satoh Yasushi, Takishima Kunio, Watanabe Yasuhiro

机构信息

Department of Pharmacology, National Defense Medical College, Tokorozawa, Japan.

出版信息

Neuroreport. 2007 May 7;18(7):659-64. doi: 10.1097/WNR.0b013e3280bef9d3.

Abstract

We initially examined the effects of apomorphine in vitro using mouse embryonic and adult neural progenitor cells. The effects of apomorphine treatment led to dose-dependent increases in the number of embryonic and adult neural progenitor cells, and dopamine D2 receptor antagonist treatment significantly reduced the increases induced by apomorphine. Next, we investigated the effects of apomorphine in vivo in the adult mouse hippocampus. The effects of single-dose apomorphine administration led to an increase of approximately 30% in the number of bromodeoxyuridine-positive cells in the dentate gyrus. Moreover, the chronic apomorphine administration induced an increase in the number of bromodeoxyuridine-positive cells by about 30%. Thus, we suggest that the stimulation of dopamine D2 receptors increases the proliferation of neural progenitor cells both in vivo and in vitro.

摘要

我们最初使用小鼠胚胎和成体神经祖细胞在体外研究了阿扑吗啡的作用。阿扑吗啡处理的作用导致胚胎和成体神经祖细胞数量呈剂量依赖性增加,并且多巴胺D2受体拮抗剂处理显著降低了阿扑吗啡诱导的增加。接下来,我们在成年小鼠海马体中研究了阿扑吗啡的体内作用。单剂量阿扑吗啡给药的作用导致齿状回中溴脱氧尿苷阳性细胞数量增加约30%。此外,慢性阿扑吗啡给药使溴脱氧尿苷阳性细胞数量增加约30%。因此,我们认为多巴胺D2受体的刺激在体内和体外均可增加神经祖细胞的增殖。

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