新型喜树碱类似物NSC606985在急性早幼粒细胞白血病小鼠模型中的治疗效果
Therapeutic efficacy of NSC606985, a novel camptothecin analog, in a mouse model of acute promyelocytic leukemia.
作者信息
Liu Wei, Zhu Yuan-Shan, Guo Meng, Yu Yun, Chen Guo-Qiang
机构信息
Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, China.
出版信息
Leuk Res. 2007 Nov;31(11):1565-74. doi: 10.1016/j.leukres.2007.03.011. Epub 2007 Apr 10.
Nanomolar concentrations of NSC606985, a novel camptothecin (CPT) analog, effectively induces apoptosis in vitro in acute myeloid leukemic (AML) cells. Here we investigated the potential therapeutic effects of NSC606985 on the mice model with acute promyelocytic leukaemia (APL), a unique subtype of AML. The results showed that NSC606985 at single dose rapidly eliminated the infiltration with apoptosis induction of leukemic cells in peripheral blood and tissues. Treatment of NSC606985 with two regimens, continuous monotherapy and intermittent long-term therapy, significantly prolonged the survival of leukemic mice with tumor regression. These results propose that NSC606985 warrants further preclinical and clinical investigations for AML treatment.
新型喜树碱（CPT）类似物NSC606985的纳摩尔浓度能在体外有效诱导急性髓系白血病（AML）细胞凋亡。在此，我们研究了NSC606985对急性早幼粒细胞白血病（APL，AML的一种独特亚型）小鼠模型的潜在治疗效果。结果显示，单剂量的NSC606985能迅速消除外周血和组织中白血病细胞的浸润并诱导其凋亡。采用连续单一疗法和间歇性长期疗法这两种方案使用NSC606985进行治疗，能显著延长白血病小鼠的生存期并使肿瘤消退。这些结果表明，NSC606985在AML治疗方面值得进一步开展临床前和临床研究。
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