乳化硅油RMN-3（奥克森HD）的核磁共振分析
Nuclear magnetic resonance analysis of emulsified silicone oil RMN-3 (Oxane HD).
作者信息
Tomlins Paul J, Woodcock Malcolm G L, Spencer Neil, Kirkby Graham R
机构信息
Birmingham and Midlands Eye Centre, Dudley Road, Birmingham, B18 7QH, UK.
出版信息
Br J Ophthalmol. 2007 Oct;91(10):1379-81. doi: 10.1136/bjo.2006.110346. Epub 2007 Apr 12.
BACKGROUND
Oxane HD is a mixture of 5700 cs silicone oil and RMN-3 (a partly fluorinated olefin), which has a specific gravity greater than water, thereby enabling endotamponade of inferior retinal breaks. Droplets of emulsified oil were found in the anterior chamber of two patients with complex retinal detachments who had been treated with Oxane HD. Samples removed from these two eyes were analysed in order to investigate the nature of the emulsified substance.
METHODS
Samples were dissolved in CDCl3 and, if necessary, dried using magnesium sulphate. Nuclear magnetic resonance (NMR) was used to compare these samples with the unused commercial product.
RESULTS
NMR analysis of the samples removed from the anterior segment of both eyes were mainly silicone oil with only trace amounts of RMN-3. Samples taken from different areas of an unused syringe of Oxane HD demonstrated varying concentrations of the RMN-3 compound within the silicone oil.
CONCLUSION
First, the mixture of RMN-3 and silicone oil is not homogenous either in vitro or in vivo. Second, emulsified oil found in the anterior chamber is composed almost entirely of silicone oil, containing only trace amounts of RMN-3.
背景
奥克生HD是一种由5700厘沲硅油和RMN - 3（一种部分氟化烯烃）组成的混合物，其比重比水大，因此可用于视网膜下方裂孔的眼内填充。在两名接受奥克生HD治疗的复杂性视网膜脱离患者的前房内发现了乳化油滴。对从这两只眼中取出的样本进行分析，以研究乳化物质的性质。
方法
将样本溶解于氘代氯仿中，必要时用硫酸镁干燥。使用核磁共振（NMR）将这些样本与未使用的商业产品进行比较。
结果
对从两只眼前节取出的样本进行的核磁共振分析显示，主要成分是硅油，仅含有痕量的RMN - 3。从未使用的奥克生HD注射器的不同部位取出的样本表明，硅油中RMN - 3化合物的浓度各不相同。
结论
第一，RMN - 3与硅油的混合物在体外和体内均不均匀。第二，在前房内发现的乳化油几乎完全由硅油组成，仅含有痕量的RMN - 3。
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