前扣带回皮质各亚区在认知和情感功能中的不同参与情况。

Differential engagement of anterior cingulate cortex subdivisions for cognitive and emotional function.

作者信息

Mohanty Aprajita, Engels Anna S, Herrington John D, Heller Wendy, Ho Moon-Ho Ringo, Banich Marie T, Webb Andrew G, Warren Stacie L, Miller Gregory A

机构信息

Institute for Neuroscience and Cognitive Neurology and Alzheimer's Disease Center, Northwestern University, Evanston, Illinois, USA.

出版信息

Psychophysiology. 2007 May;44(3):343-51. doi: 10.1111/j.1469-8986.2007.00515.x.

DOI:10.1111/j.1469-8986.2007.00515.x

PMID:17433093

Abstract

Functional differentiation of dorsal (dACC) and rostral (rACC) anterior cingulate cortex for cognitive and emotional function has received considerable indirect support. Using fMRI, parallel tasks, and within-subject analysis, the present study directly tested the proposed specialization of ACC subdivisions. A Task x Region interaction confirmed more dACC activation during color-word distractors and more rACC activation during emotion-word distractors. Activity in ACC subdivisions differentially predicted behavioral performance. Connectivity with prefrontal and limbic regions also supported distinct dACC and rACC roles. Findings provide direct evidence for differential engagement of ACC subdivisions in cognitive and emotional processing and for differential functional connectivity in the implementation of cognitive control and emotion regulation. Results point to an anatomical and functional continuum rather than segregated operations.

摘要

背侧前扣带回皮质（dACC）和吻侧前扣带回皮质（rACC）在认知和情感功能方面的功能分化已得到相当多的间接支持。本研究采用功能磁共振成像（fMRI）、并行任务和受试者内分析，直接检验了所提出的前扣带回皮质各亚区的专门化。一项任务×区域交互作用证实，在颜色词干扰期间dACC激活更多，在情绪词干扰期间rACC激活更多。前扣带回皮质各亚区的活动对行为表现的预测存在差异。与前额叶和边缘区域的连接也支持dACC和rACC的不同作用。研究结果为前扣带回皮质各亚区在认知和情感加工中的不同参与以及在认知控制和情绪调节实施中的不同功能连接提供了直接证据。结果指向一个解剖学和功能上的连续体，而非分离的操作。