Stockinger Brigitta, Veldhoen Marc
Division of Molecular Immunology, The MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London, UK. .
Curr Opin Immunol. 2007 Jun;19(3):281-6. doi: 10.1016/j.coi.2007.04.005. Epub 2007 Apr 12.
IL-17-producing T cells have recently been classified as a new effector T-cell subset, termed Th17, which is distinct from Th1, Th2 and Treg subsets. There has been much progress in the past year, leading to identification of the molecular mechanisms that drive differentiation of Th17 T cells. This has helped to clarify many aspects of their role in host defense as well as in autoimmunity. Nevertheless, many intriguing questions remain to be answered regarding the regulation of Th17-mediated responses as well as their interactions with the other T-cell subsets. Furthermore, the role of pathogens and pathogen-derived molecules in influencing effector T-cell polarization needs to be re-evaluated in the light of the differentiation conditions that favor Th17 T-cell responses.
产生白细胞介素-17的T细胞最近被归类为一个新的效应T细胞亚群，称为Th17，它不同于Th1、Th2和调节性T细胞亚群。在过去的一年里取得了很大进展，从而确定了驱动Th17 T细胞分化的分子机制。这有助于阐明它们在宿主防御以及自身免疫中作用的许多方面。然而，关于Th17介导的反应的调节及其与其他T细胞亚群的相互作用，仍有许多有趣的问题有待解答。此外，鉴于有利于Th17 T细胞反应的分化条件，病原体和病原体衍生分子在影响效应T细胞极化中的作用需要重新评估。
