儿童初发急性淋巴细胞白血病中髓系标志物的频繁而非随机表达

Frequent but nonrandom expression of myeloid markers on de novo childhood acute lymphoblastic leukemia.

作者信息

Abdelhaleem Mohamed

机构信息

Division of Haematopathology, Department of Paediatric Laboratory Medicine, Rm 3691, Atrium, Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada M5G 1X8.

出版信息

Exp Mol Pathol. 2007 Aug;83(1):138-41. doi: 10.1016/j.yexmp.2007.02.004. Epub 2007 Feb 24.

DOI:10.1016/j.yexmp.2007.02.004

PMID:17434163

Abstract

The expression of the myeloid markers CD13, CD33, and CD15 in two hundred and eighty-three cases of de novo childhood acute lymphoblastic leukemia (ALL) is examined. The expression of at least one marker is a frequent event which is noted in 64% and 74% of B- and T-lineage ALL cases, respectively. Certain patterns of myeloid antigen expression can be recognized including: no expression of CD13, CD33, and CD15 in mature B-ALL, significantly higher levels of CD13 and CD33 and significantly lower levels of CD15 in TEL-AML1-positive B cell precursor ALL, no expression of CD13 and CD33 in E2A-PBX1-positive B cell precursor ALL cases and common T-ALL (double positive for CD4 and CD8), and no expression of CD13 in MLL-AF4-positive B cell precursor ALL cases. Although the numbers in some ALL subtypes are small, these patterns are consistent with nonrandom expression of myeloid markers in de novo childhood ALL.

摘要

检测了283例儿童初发急性淋巴细胞白血病（ALL）中髓系标志物CD13、CD33和CD15的表达情况。至少一种标志物的表达很常见，在B系和T系ALL病例中分别有64%和74%出现这种情况。可以识别出某些髓系抗原表达模式，包括：成熟B-ALL中CD13、CD33和CD15均无表达；TEL-AML1阳性B细胞前体ALL中CD13和CD33水平显著升高，CD15水平显著降低；E2A-PBX1阳性B细胞前体ALL病例和常见T-ALL（CD4和CD8双阳性）中CD13和CD33无表达；MLL-AF4阳性B细胞前体ALL病例中CD13无表达。尽管某些ALL亚型的病例数较少，但这些模式与儿童初发ALL中髓系标志物的非随机表达一致。