Crum-Cianflone Nancy F
Clinical Investigation Department (KCA), Naval Medical Center San Diego, 34800 Bob Wilson Drive, Ste. 5, San Diego, CA 92134-1005, USA.
Ann N Y Acad Sci. 2007 Sep;1111:112-21. doi: 10.1196/annals.1406.001. Epub 2007 Apr 13.
Coccidioidomycosis has had an impact on the military since the discovery of the causative agent, Coccidioides immitis, over a century ago. The first reports of Coccidioides outbreaks affecting U.S. military personnel were reported by Smith and others during World War II. Since that time, numerous outbreaks and sporadic cases have occurred, affecting both the health and readiness of our armed forces. This article summarizes the impact of Coccidioides sp. on our military troops with a review of the literature, a description of the experience at a tertiary referral hospital treating the disease, and a synopsis of incidence studies conducted at bases in the southwestern United States. The substantial effect that coccidioidomycosis has had on the military supports the development of both newer and more effective treatments as well as a Valley Fever vaccine for prevention of this disease.
自一个多世纪前发现致病因子球孢子菌以来，球孢子菌病就对军队产生了影响。史密斯等人在第二次世界大战期间报告了首批影响美国军事人员的球孢子菌病暴发。从那时起，发生了多次暴发和散发病例，影响了我们武装部队的健康和战备状态。本文通过文献综述、对一家治疗该病的三级转诊医院经验的描述以及对美国西南部基地进行的发病率研究的概述，总结了球孢子菌对我们军队的影响。球孢子菌病对军队产生的重大影响支持研发更新、更有效的治疗方法以及用于预防该病的谷热疫苗。
