Schneider David F, Glenn Cavin H, Faunce Douglas E
Department of Surgery, Burn and Shock Trauma Institute, Loyola University Medical Center, Bldg 110, Room 4236, 2160 South 1st Avenue, Maywood, Illinois 60153, USA.
J Burn Care Res. 2007 May-Jun;28(3):365-79. doi: 10.1097/BCR.0B013E318053D40B.
The vast majority of clinical and basic science research on the immune consequences of burn injury and sepsis conducted during the last three decades has focused mainly on the roles of macrophages, neutrophils and, to a lesser extent, conventional T lymphocytes. During recent years, however, it has become increasingly clear that minor subsets of innate immune cells, innate regulatory lymphocytes in particular, are central to processes involved in both protective immunity and immunopathology. Recent reports by our laboratory and others have just begun to shed light on the critical roles of innate lymphocyte subsets, including natural killer T cells, natural killer cells, gamma-delta T cells, and naturally occurring CD4+CD25+ regulatory T cells during the immune response to burn injury and sepsis. Given their emerging importance and documented upstream regulatory capacities over macrophage, dendritic cell, and T lymphocyte functions, innate regulatory lymphocytes represent attractive new targets for therapeutic intervention for the overall immune paralysis that occurs with injury and sepsis. Here, we provide an overview of the current state of knowledge of these particular cell subsets in the immune response to burn injury and sepsis.
在过去三十年中，关于烧伤和脓毒症免疫后果的绝大多数临床和基础科学研究主要集中在巨噬细胞、中性粒细胞以及在较小程度上传统T淋巴细胞的作用上。然而，近年来越来越清楚的是，先天免疫细胞的一些小亚群，特别是先天调节性淋巴细胞，对于保护性免疫和免疫病理学所涉及的过程至关重要。我们实验室和其他机构最近的报告刚刚开始揭示先天淋巴细胞亚群在烧伤和脓毒症免疫反应中的关键作用，这些亚群包括自然杀伤T细胞、自然杀伤细胞、γδT细胞和天然存在的CD4+CD25+调节性T细胞。鉴于它们新出现的重要性以及对巨噬细胞、树突状细胞和T淋巴细胞功能已记录的上游调节能力，先天调节性淋巴细胞是针对损伤和脓毒症时发生的整体免疫麻痹进行治疗干预的有吸引力的新靶点。在此，我们概述了在烧伤和脓毒症免疫反应中这些特定细胞亚群的当前知识状态。
