肌浆球蛋白和受磷蛋白作为心肌肌浆网Ca2+ ATP酶的调节因子。
Sarcolipin and phospholamban as regulators of cardiac sarcoplasmic reticulum Ca2+ ATPase.
作者信息
Bhupathy Poornima, Babu Gopal J, Periasamy Muthu
机构信息
Department of Physiology and Cell Biology, The Ohio State University, Columbus, OH 43210, USA.
出版信息
J Mol Cell Cardiol. 2007 May;42(5):903-11. doi: 10.1016/j.yjmcc.2007.03.738. Epub 2007 Mar 12.
Abstract
The cardiac sarcoplasmic reticulum calcium ATPase (SERCA2a) plays a critical role in maintaining the intracellular calcium homeostasis during cardiac contraction and relaxation. It has been well documented over the years that altered expression and activity of SERCA2a can lead to systolic and diastolic dysfunction. The activity of SERCA2a is regulated by two structurally similar proteins, phospholamban (PLB) and sarcolipin (SLN). Although, the relevance of PLB has been extensively studied over the years, the role SLN in cardiac physiology is an emerging field of study. This review focuses on the advances in the understanding of the regulation of SERCA2a by SLN and PLB. In particular, it highlights the similarities and differences between the two proteins and their roles in cardiac patho-physiology.
摘要
心脏肌浆网钙ATP酶（SERCA2a）在心脏收缩和舒张过程中维持细胞内钙稳态方面起着关键作用。多年来已有充分记录表明，SERCA2a表达和活性的改变可导致收缩和舒张功能障碍。SERCA2a的活性受两种结构相似的蛋白质——受磷蛋白（PLB）和肌浆蛋白（SLN）调节。尽管多年来对PLB的相关性进行了广泛研究，但SLN在心脏生理学中的作用仍是一个新兴的研究领域。本综述重点关注对SLN和PLB调节SERCA2a的认识进展。特别是，它突出了这两种蛋白质之间的异同及其在心脏病理生理学中的作用。
相似文献
1
Sarcolipin and phospholamban as regulators of cardiac sarcoplasmic reticulum Ca2+ ATPase.
J Mol Cell Cardiol. 2007 May;42(5):903-11. doi: 10.1016/j.yjmcc.2007.03.738. Epub 2007 Mar 12.
2
Phospholamban and sarcolipin: Are they functionally redundant or distinct regulators of the Sarco(Endo)Plasmic Reticulum Calcium ATPase?
J Mol Cell Cardiol. 2016 Feb;91:81-91. doi: 10.1016/j.yjmcc.2015.12.030. Epub 2015 Dec 29.
3
Sarcolipin and phospholamban inhibit the calcium pump by populating a similar metal ion-free intermediate state.
Biochem Biophys Res Commun. 2015;463(1-2):37-41. doi: 10.1016/j.bbrc.2015.05.012. Epub 2015 May 15.
4
The N Terminus of Sarcolipin Plays an Important Role in Uncoupling Sarco-endoplasmic Reticulum Ca2+-ATPase (SERCA) ATP Hydrolysis from Ca2+ Transport.
J Biol Chem. 2015 May 29;290(22):14057-67. doi: 10.1074/jbc.M115.636738. Epub 2015 Apr 16.
5
Cardiac-specific overexpression of sarcolipin inhibits sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA2a) activity and impairs cardiac function in mice.
Proc Natl Acad Sci U S A. 2004 Jun 22;101(25):9199-204. doi: 10.1073/pnas.0402596101. Epub 2004 Jun 16.
6
Conformational memory in the association of the transmembrane protein phospholamban with the sarcoplasmic reticulum calcium pump SERCA.
J Biol Chem. 2017 Dec 29;292(52):21330-21339. doi: 10.1074/jbc.M117.794453. Epub 2017 Oct 29.
7
Sarcolipin and phospholamban mRNA and protein expression in cardiac and skeletal muscle of different species.
Biochem J. 2005 Jul 1;389(Pt 1):151-9. doi: 10.1042/BJ20050068.
8
Sarcolipin protein interaction with sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA) is distinct from phospholamban protein, and only sarcolipin can promote uncoupling of the SERCA pump.
J Biol Chem. 2013 Mar 8;288(10):6881-9. doi: 10.1074/jbc.M112.436915. Epub 2013 Jan 22.
9
[Research progress of sarcolipin-a new regulatory protein of sarcoplasmic reticulum Ca2+ ATPase].
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2012 Mar;37(3):316-9. doi: 10.3969/j.issn.1672-7347.2012.03.019.
10
The sarcolipin-bound calcium pump stabilizes calcium sites exposed to the cytoplasm.
Nature. 2013 Mar 14;495(7440):265-9. doi: 10.1038/nature11900. Epub 2013 Mar 3.
引用本文的文献
1
Crucial roles of calcium ATPases and phosphoinositides: Insights into pathophysiology and therapeutic strategies.
Mol Cells. 2025 Jul 11;48(9):100254. doi: 10.1016/j.mocell.2025.100254.
2
Environment-induced heat stress causes ventricular-dependent biochemical changes in the heart in female pigs.
Physiol Rep. 2025 Jun;13(11):e70414. doi: 10.14814/phy2.70414.
3
Emerging roles for microproteins as critical regulators of endoplasmic reticulum function and cellular homeostasis.
Semin Cell Dev Biol. 2025 Jun;170:103608. doi: 10.1016/j.semcdb.2025.103608. Epub 2025 Apr 17.
4
The juxtamembrane sequence of small ankyrin 1 mediates the binding of its cytoplasmic domain to SERCA1 and is required for inhibitory activity.
J Biol Chem. 2025 Mar;301(3):108216. doi: 10.1016/j.jbc.2025.108216. Epub 2025 Jan 23.
5
Adaptive Induction of Nonshivering Thermogenesis in Muscle Rather Than Brown Fat Could Counteract Obesity.
Physiol Res. 2024 Aug 30;73(S1):S279-S294. doi: 10.33549/physiolres.935361. Epub 2024 May 15.
6
Endurance Exercise Training Mitigates Diastolic Dysfunction in Diabetic Mice Independent of Phosphorylation of Ulk1 at S555.
Int J Mol Sci. 2024 Jan 3;25(1):633. doi: 10.3390/ijms25010633.
7
Replacement of Lys27 by asparagine in the SERCA regulator myoregulin: A Ca affinity modulator or a catalytic activity switch?
Biochim Biophys Acta Mol Cell Res. 2024 Jan;1871(1):119613. doi: 10.1016/j.bbamcr.2023.119613. Epub 2023 Nov 2.
8
Non-shivering thermogenesis is differentially regulated during the hibernation season in Arctic ground squirrels.
Front Physiol. 2023 Jul 13;14:1207529. doi: 10.3389/fphys.2023.1207529. eCollection 2023.
9
Ion Channels of the Sarcolemma and Intracellular Organelles in Duchenne Muscular Dystrophy: A Role in the Dysregulation of Ion Homeostasis and a Possible Target for Therapy.
Int J Mol Sci. 2023 Jan 23;24(3):2229. doi: 10.3390/ijms24032229.
10
Recruitment of Muscle Genes as an Effect of Brown Adipose Tissue Ablation in Cold-Acclimated Brandt's Voles ().
Int J Mol Sci. 2022 Dec 25;24(1):342. doi: 10.3390/ijms24010342.
本文引用的文献
1
Role of Ca2+/calmodulin-dependent protein kinase (CaMK) in excitation-contraction coupling in the heart.
Cardiovasc Res. 2007 Mar 1;73(4):631-40. doi: 10.1016/j.cardiores.2006.11.005. Epub 2006 Nov 10.
2
New perspectives on the role of SERCA2's Ca2+ affinity in cardiac function.
Biochim Biophys Acta. 2006 Nov;1763(11):1216-28. doi: 10.1016/j.bbamcr.2006.08.025. Epub 2006 Aug 25.
3
Post-transcriptional downregulation of sarcolipin mRNA by triiodothyronine in the atrial myocardium.
FEBS Lett. 2006 Apr 17;580(9):2247-52. doi: 10.1016/j.febslet.2006.03.032. Epub 2006 Mar 20.
4
Defining the intramembrane binding mechanism of sarcolipin to calcium ATPase using solution NMR spectroscopy.
J Mol Biol. 2006 Apr 28;358(2):420-9. doi: 10.1016/j.jmb.2006.02.005. Epub 2006 Feb 20.
5
Cardiac-specific overexpression of sarcolipin in phospholamban null mice impairs myocyte function that is restored by phosphorylation.
Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2446-51. doi: 10.1073/pnas.0510883103. Epub 2006 Feb 6.
6
A mutation in the human phospholamban gene, deleting arginine 14, results in lethal, hereditary cardiomyopathy.
Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1388-93. doi: 10.1073/pnas.0510519103. Epub 2006 Jan 23.
7
Targeted overexpression of sarcolipin in the mouse heart decreases sarcoplasmic reticulum calcium transport and cardiac contractility.
J Biol Chem. 2006 Feb 17;281(7):3972-9. doi: 10.1074/jbc.M508998200. Epub 2005 Dec 19.
8
Sarcolipin and phospholamban mRNA and protein expression in cardiac and skeletal muscle of different species.
Biochem J. 2005 Jul 1;389(Pt 1):151-9. doi: 10.1042/BJ20050068.
9
The alpha-helical propensity of the cytoplasmic domain of phospholamban: a molecular dynamics simulation of the effect of phosphorylation and mutation.
Biophys J. 2005 May;88(5):3243-51. doi: 10.1529/biophysj.104.054460. Epub 2005 Mar 11.
10
Overexpression of sarcolipin decreases myocyte contractility and calcium transient.
Cardiovasc Res. 2005 Jan 1;65(1):177-86. doi: 10.1016/j.cardiores.2004.08.012.
Zotero 插件