Xie Shi-guang, Cai Bai-qiang, Zhang Hong, Liu Yong-jian, Liu Tao
Department of Respiratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing 100730, China.
Zhonghua Nei Ke Za Zhi. 2007 Feb;46(2):118-22.
To study the safety and effectiveness of bilateral sequential whole lung lavage in the same treatment session for pulmonary alveolar proteinosis.
Twelve times bilateral sequential whole lung lavage in the same treatment session were performed under general anaesthesia using a double lumen endotracheal tube for 10 cases of pulmonary alveolar proteinosis. The volume of lavage, return volume and the return rate were calculated. The efficacy was evaluated according to the improvement of symptoms, pulmonary function and arterial blood gas analysis data.
Twelve times bilateral sequential whole lung lavage in the same treatment session were performed successfully for the 10 cases of pulmonary alveolar proteinosis. The total volume of lavage was (26,417+/-7,064) ml, the return volume was (25,962+/-7,023) ml, the time of lavage was (192+/-26) minutes. The symptoms and chest radiograph were improved immediately after the procedure for all patients. The alveolar to arterial oxygen tension difference was decreased significantly. Arterial oxygen tensions were increased but no significant difference was reached. There was no significant immediate improvement for the pulmonary function. No complications were noted but pulmonary edema in one patient.
Bilateral sequential whole lung lavage in the same treatment session is a safe and effective procedure for treatment of pulmonary alveolar proteinosis.
研究在同一治疗疗程中进行双侧序贯全肺灌洗治疗肺泡蛋白沉积症的安全性和有效性。
对10例肺泡蛋白沉积症患者在全身麻醉下使用双腔气管导管在同一治疗疗程中进行12次双侧序贯全肺灌洗。计算灌洗量、回流量及回流率。根据症状改善情况、肺功能及动脉血气分析数据评估疗效。
10例肺泡蛋白沉积症患者在同一治疗疗程中成功进行了12次双侧序贯全肺灌洗。灌洗总量为（26417±7064）ml，回流量为（25962±7023）ml，灌洗时间为（192±26）分钟。所有患者术后症状及胸部X线片立即改善。肺泡 - 动脉氧分压差显著降低。动脉血氧分压升高但未达到显著差异。肺功能无明显即刻改善。未观察到并发症，但有1例患者出现肺水肿。
在同一治疗疗程中进行双侧序贯全肺灌洗是治疗肺泡蛋白沉积症的一种安全有效的方法。
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