ST/HR slope and improved exercise ECG detection of myocardial ischemia in patients with suspected coronary artery disease.

Predictive values of ST/HR slope and ST-segment displacement during symptom-limited exercise were determined in 85 patients who underwent coronary angiography for suspected coronary artery disease, using perfusional and functional radionuclide images with 99mTc-2-methoxy-isobutil-isonitrile as an index of stress-induced myocardial ischemia. ST/HR slope showed a better sensitivity than conventional stress-induced changes of ST-segment displacement (96% vs. 73%, respectively). In patients with clinical suspicion of coronary artery disease, the main result was the negative predictive value of ST/HR slope when compared with conventional ST-segment displacement (98% vs. 41%). ST/HR slope was unable to perfectly separate patients with different degrees of ischemia, however, subjects without scintigraphic signs of stress-induced ischemia and patients with ischemic impairment in three myocardial regions were correctly identified as distinct populations. In patients with a previous myocardial infarction, no difference was found between the two criteria and a wide overlap of ST/HR slope values was present. The authors conclude that ST/HR slope is useful to detect the rate of change in electric parameters during exercise and might therefore more adequately be used to separate normal from definitely abnormal responses to exercise.