van Gool J D, de Jong T P, Boemers T M
Pädiatrisches Nierenzentrum, Universitätsklinik für Kinder und Jugendliche Het Wilhelmina Kinderziekenhuis, Utrecht.
Monatsschr Kinderheilkd. 1991 Sep;139(9):592-6.
Although the primary objective of clean intermittent (self) catheterization (CIC) was to regain continence in (older) children with myelomeningocele (MMC), we used the method also in the very young with detrusor-sphincter dyssynergia, to prevent future damage from the combined effects of obstruction and urinary tract infection (UTI). The results, in terms of incidence of UTI and degree of incontinence before and during CIC, were assessed in 61 children with MMC who had started CIC between 1985 and 1988. Mean follow up was 45.3 +/- 27.3 months, mean age at the start of CIC was 6.9 +/- 4.6 years. The incidence of UTI during CIC proved significantly lower than before CIC (chi 2 = 20.92, p less than 0.001), and the improvement in incontinence was also statistically significant (chi 2 = 45.16, p less than 0.001). In children with MMC, CIC seems ideally suited to prevent damage to the kidneys from the life-long problem of recurrent UTI's. It will also help in preventing bladder wall fibrosis--an important cause of loss of detrusor compliance--secondary to repeated UTIs.
尽管清洁间歇性(自我)导尿(CIC)的主要目标是使患有脊髓脊膜膨出(MMC)的(大龄)儿童恢复控尿能力,但我们也将该方法用于患有逼尿肌-括约肌协同失调的幼儿,以防止梗阻和尿路感染(UTI)的综合影响造成未来损害。对1985年至1988年间开始进行CIC的61例MMC患儿,评估了CIC前后UTI发生率和尿失禁程度的结果。平均随访时间为45.3±27.3个月,CIC开始时的平均年龄为6.9±4.6岁。结果显示,CIC期间UTI的发生率显著低于CIC前(χ2 = 20.92,p < 0.001),尿失禁的改善在统计学上也具有显著意义(χ2 = 45.16,p < 0.001)。对于MMC患儿,CIC似乎非常适合预防复发性UTI这一终身问题对肾脏造成的损害。它还有助于预防膀胱壁纤维化——这是逼尿肌顺应性丧失的一个重要原因——继发于反复的UTI。