与 AMP 和 ZMP 结合的人 AMPK 调节性 γ1 亚基的 CBS 结构域对的结构
Structure of a CBS-domain pair from the regulatory gamma1 subunit of human AMPK in complex with AMP and ZMP.
作者信息
Day Philip, Sharff Andrew, Parra Lina, Cleasby Anne, Williams Mark, Hörer Stefan, Nar Herbert, Redemann Norbert, Tickle Ian, Yon Jeff
机构信息
Astex Therapeutics Ltd, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, England.
出版信息
Acta Crystallogr D Biol Crystallogr. 2007 May;63(Pt 5):587-96. doi: 10.1107/S0907444907009110. Epub 2007 Apr 21.
AMP-activated kinase (AMPK) is central to sensing energy status in eukaryotic cells via binding of AMP and ATP to CBS (cystathionine beta-synthase) domains in the regulatory gamma subunit. The structure of a CBS-domain pair from human AMPK gamma1 in complex with the physiological activator AMP and the pharmacological activator ZMP (AICAR) is presented.
AMP激活的蛋白激酶（AMPK）通过在调节性γ亚基中使AMP和ATP与CBS（胱硫醚β-合酶）结构域结合，在真核细胞感知能量状态方面起着核心作用。本文展示了来自人AMPKγ1的一对CBS结构域与生理激活剂AMP和药理激活剂ZMP（AICAR）形成复合物的结构。
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