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肉毒杆菌毒素在下颌髁突骨折闭合治疗中的应用

Botulinum toxin in closed treatment of mandibular condylar fracture.

作者信息

Canter Halil Ibrahim, Kayikcioglu Aycan, Aksu Muge, Mavili Mehmet Emin

机构信息

Hacettepe University, Faculty of Medicine, Department of Plastic and Reconstructive Surgery, Ankara, Turkey.

出版信息

Ann Plast Surg. 2007 May;58(5):474-8. doi: 10.1097/01.sap.0000244987.68092.6e.

Abstract

BACKGROUND

The topic of condylar injury in adults has generated more discussion and controversy than any other in the field of maxillofacial trauma. The treatment of condylar fractures in adults is still a highly debated theme.

METHODS

Patients with unilateral subcondylar or condylar neck fractures of the mandibula without any significant angulation of the condylar head were managed with closed-treatment protocol. Closed treatment was applied through the injection of 100 units of botulinum toxin A, diluted to a concentration of 20 IU/mL, into the muscles of mastication of the fractured side. Masseter and anterior fibers of temporalis muscles were reached through percutaneous extraoral route and 30 IU of the toxin was injected to each muscle. Additional 40 IU of the toxin was injected around the fractured bone fragments through transmucosal intraoral route to paralyze medial and lateral pterygoid muscles as much as possible. An asymmetric occlusal splint was applied for maxillomandibular fixation to restore the vertical height for 10 days. Functional therapy with intermaxillary guiding elastics was advocated for 2 months.

RESULTS

There were no complications related to either toxin injections or splint application procedures. The toxin was effective on all occasions. Fractured condylar process and ramus of the mandibula were in good approximation and remained in reduced positions. None of the patients had any occlusal disturbance, mandibular asymmetry, or joint dysfunction in the follow-up period.

CONCLUSIONS

We believe that modification of treatment options concerning the clinical situation of the patients is the best method for condylar injury. The purpose of this study is to present and discuss the results achieved in closed treatment of a selected group of patients with mandibular condylar fractures to whom botulinum toxin A was injected to relieve the spasm of muscles of mastication, along with special splint application.

摘要

背景

在颌面部创伤领域,成人髁突损伤这一话题引发的讨论和争议比其他任何话题都要多。成人髁突骨折的治疗仍是一个备受争议的主题。

方法

对下颌骨单侧髁突下或髁突颈部骨折且髁突头部无明显成角的患者采用闭合治疗方案。通过将100单位肉毒杆菌毒素A稀释至浓度为20 IU/mL,注射到骨折侧的咀嚼肌中来进行闭合治疗。通过经皮口外途径到达咬肌和颞肌前纤维,向每块肌肉注射30 IU毒素。另外40 IU毒素通过经黏膜口内途径注射到骨折骨碎片周围,以尽可能麻痹翼内肌和翼外肌。应用不对称咬合夹板进行颌间固定,以恢复垂直高度10天。提倡使用颌间引导弹性牵引进行功能治疗2个月。

结果

毒素注射或夹板应用过程均未出现并发症。毒素在所有情况下均有效。下颌骨骨折的髁突和升支贴合良好,保持复位状态。在随访期间,所有患者均未出现咬合紊乱、下颌不对称或关节功能障碍。

结论

我们认为根据患者的临床情况调整治疗方案是治疗髁突损伤的最佳方法。本研究的目的是展示并讨论对一组选定的下颌髁突骨折患者进行闭合治疗的结果,这些患者注射了肉毒杆菌毒素A以缓解咀嚼肌痉挛,并配合特殊夹板应用。

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