Matschke K, Gerk U, Mrowietz C, Park J-W, Jung F
Department of Cardiac Surgery, Heart Center Dresden, Technical University, Dresden, Germany.
Acta Radiol. 2007 Apr;48(3):292-9. doi: 10.1080/02841850701209956.
To examine how a one-time bolus injection of radiographic contrast media (RCM; iodixanol 320 and iomeprol 350) into the left coronary artery of six pigs affects tissue oxygen tension in the artery's supply area (pO(2 )LAD) compared to a 0.9% sodium-chloride (NaCl) bolus.
Each animal received a total of three boluses: one iodixanol, one iomeprol, and one NaCl (10 ml each). The radiographic contrast media and NaCl boluses were randomly assigned, and pO(2) profiles were recorded.
26.7+/-16.4 s after iodixanol injection, pO(2) LAD had declined by 3.5% from 42.2+/-5.6 mmHg to 40.7+/-5.9 mmHg (P = 0.0357). After 53+/-16.7 s, the initial value was restored. The pO(2) LAD was 41.9+/-7.4 mmHg before iomeprol injection, and, 303.3+/-58.9 s after injection, pO(2) LAD had declined by 13.1% to 36.4+/-7.5 mmHg (P = 0.0001). After 577+/-22 s, the initial value was restored. The bolus application of an isotonic NaCl solution resulted in no effect on pO(2) LAD. Immediately after injection, it increased by 3%. In the supply area of the right coronary artery and the peripheral skeletal muscle, no effect of the RCM or NaCl on tissue oxygen tension was observed. Furthermore, no effect on tissue temperature, heart rate, systolic and diastolic blood pressure, or cardiac output per minute occurred.
The injection of RCM in a coronary artery can result in a significant local contrast-medium-induced microcirculation disorder. The high viscosity of iodixanol led to a very short-term insignificant effect on the microcirculation, while iomeprol induced a slight time-delayed pO(2) decrease, which might be caused by the rigidification of erythrocytes. In comparison to a previous study with iopromide, the influence of iodixanol and iomeprol on myocardial oxygen tension was markedly less pronounced.
研究一次性向六只猪的左冠状动脉推注放射性造影剂（RCM；碘克沙醇320和碘美普尔350）与推注0.9%氯化钠（NaCl）相比，对动脉供血区域组织氧张力（pO₂ LAD）的影响。
每只动物共接受三次推注：一次碘克沙醇、一次碘美普尔和一次NaCl（每次10毫升）。放射性造影剂和NaCl推注随机分配，并记录pO₂ 曲线。
注射碘克沙醇后26.7±16.4秒，pO₂ LAD从42.2±5.6 mmHg下降了3.5%至40.7±5.9 mmHg（P = 0.0357）。53±16.7秒后，恢复到初始值。注射碘美普尔前pO₂ LAD为41.9±7.4 mmHg，注射后303.3±58.9秒，pO₂ LAD下降了13.1%至36.4±7.5 mmHg（P = 0.0001）。577±22秒后，恢复到初始值。推注等渗NaCl溶液对pO₂ LAD无影响。注射后立即升高了3%。在右冠状动脉供血区域和外周骨骼肌中，未观察到RCM或NaCl对组织氧张力的影响。此外，对组织温度、心率、收缩压和舒张压或每分钟心输出量均无影响。
冠状动脉内注射RCM可导致显著的局部造影剂诱导的微循环障碍。碘克沙醇的高粘度对微循环产生了非常短暂的不显著影响，而碘美普尔则导致pO₂ 略有延迟下降，这可能是由红细胞硬化引起的。与先前关于碘普罗胺的研究相比，碘克沙醇和碘美普尔对心肌氧张力的影响明显不那么显著。
