Rappeport E D, Loft A, Berthelsen A K, von der Recke P, Larsen P Noergaard, Mogensen A Mellon, Wettergren A, Rasmussen A, Hillingsoe J, Kirkegaard P, Thomsen C
Department of Radiology, Centre of Diagnostic Investigations, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Acta Radiol. 2007 May;48(4):369-78. doi: 10.1080/02841850701294560.
BACKGROUND: The choice of imaging before liver surgery is debated regarding the use of magnetic resonance (MR) imaging, computed tomography (CT), and positron emission tomography (PET). No studies have compared contrast-enhanced PET/CT with superparamagnetic iron oxide (SPIO)-enhanced MR imaging. PURPOSE: To compare PET/CT with superparamagnetic iron oxide (SPIO)-enhanced MR imaging, PET, and CT in the detection of liver metastases (LM) and extrahepatic tumor from colorectal cancer (CRC). MATERIAL AND METHODS: Thirty-five patients with suspected LM underwent PET/CT with a contrast-enhanced CT protocol and SPIO-enhanced MR imaging. Readers independently analyzed images from MR imaging, PET/CT, and the CT part and PET part of the PET/CT study. Imaging findings were compared with surgical and histological findings. RESULTS: Lesion-by-lesion sensitivity and accuracy for liver lesions was 54% and 77% for PET alone, 66% and 83% for PET/CT, 82% and 82% for SPIO-enhanced MR imaging, and 89% and 77% for CT alone, respectively. CT and SPIO-enhanced MR imaging were less specific but significantly more sensitive than PET (P<0.0001). For extrahepatic tumor, sensitivity and specificity was 83% and 96% for PET/CT and 58% and 87% for CT, respectively. CONCLUSION: CT and SPIO-enhanced MR imaging are more sensitive but less specific than PET in the detection of LM. PET/CT can detect more patients with extrahepatic tumor than CT alone.
背景：关于肝脏手术前成像检查的选择，磁共振成像（MR）、计算机断层扫描（CT）和正电子发射断层扫描（PET）的使用存在争议。尚无研究对比过对比增强PET/CT与超顺磁性氧化铁（SPIO）增强MR成像。 目的：比较PET/CT、超顺磁性氧化铁（SPIO）增强MR成像、PET和CT在检测结直肠癌（CRC）肝转移（LM）和肝外肿瘤方面的效果。 材料与方法：35例疑似LM患者接受了采用对比增强CT方案的PET/CT及SPIO增强MR成像检查。阅片者独立分析MR成像、PET/CT以及PET/CT检查中CT部分和PET部分的图像。将成像检查结果与手术及组织学检查结果进行比较。 结果：对于肝脏病变，PET单独检查的逐病灶敏感性和准确性分别为54%和77%，PET/CT为66%和83%，SPIO增强MR成像为82%和82%，CT单独检查为89%和77%。CT和SPIO增强MR成像的特异性较低，但敏感性显著高于PET（P<0.0001）。对于肝外肿瘤，PET/CT的敏感性和特异性分别为83%和96%，CT为58%和87%。 结论：在检测LM方面，CT和SPIO增强MR成像比PET更敏感，但特异性更低。PET/CT比单独CT能检测出更多有肝外肿瘤的患者。
Ann Coloproctol. 2024-4
World J Radiol. 2015-7-28
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