Selek Handan, Sahin Selma, Kas H Suheyla, Hincal A Atilla, Ponchel Gilles, Ercan Meral T, Sargon Mustafa
Faculty of Pharmacy, Hacettepe University, Ankara, Turkey.
Drug Dev Ind Pharm. 2007 Feb;33(2):147-54. doi: 10.1080/03639040600735046.
Preparation of starch microspheres using epichlorohydrin is a time consuming method and requires around 18 hr for cross-linking reaction. To reduce reaction time, terbutaline sulfate (TBS) loaded degradable starch microspheres (DSM) were prepared using formaldehyde as the cross-linking agent. All microspheres were spherical in shape and had a porous, rough surface with a mean particle size of 18-24 microm. Whatever the cross-linking time, it was seen that the release of the TBS was not complete during the release experiments. The influence of enzyme on the degradation of microspheres was moderate. Following intravenous administration, initial uptake of microspheres by the lung was higher than those of other organs.
使用环氧氯丙烷制备淀粉微球是一种耗时的方法，交联反应大约需要18小时。为了缩短反应时间，以甲醛为交联剂制备了负载硫酸特布他林（TBS）的可降解淀粉微球（DSM）。所有微球均呈球形，表面多孔且粗糙，平均粒径为18 - 24微米。无论交联时间如何，在释放实验中都可以看到TBS的释放并不完全。酶对微球降解的影响适中。静脉给药后，肺部对微球的初始摄取高于其他器官。
