几种红霉素A溶剂化物的晶体学表征：晶格中溶剂分子的环境
Crystallographic characterization of several erythromycin A solvates: the environment of the solvent molecules in the crystal lattice.
作者信息
Henry Rodger, Zhang Geoff G Z
机构信息
Structural Chemistry, Global Pharmaceutical R & D, Abbott Laboratories, 100 Abbott Park Rd., Abbott Park, Illinois 60064, USA.
出版信息
J Pharm Sci. 2007 May;96(5):1251-7. doi: 10.1002/jps.20917.
PMID:17455320
Abstract
Four solvates of erythromycin have been crystallographically characterized. The solvates of THF and dioxane are very similar but differ in notable ways. The isopropanol solvate exhibits uncommon modes of hydrogen bonding, which have previously been seen only in the erythomycin B hydrate. The methanol solvate is strikingly similar to the methanol solvate of 6-O-methyl erythromycin.
摘要
四种红霉素溶剂化物已通过晶体学表征。四氢呋喃（THF）和二氧六环的溶剂化物非常相似，但在一些显著方面存在差异。异丙醇溶剂化物表现出不常见的氢键模式，此前仅在红霉素B水合物中见过。甲醇溶剂化物与6-O-甲基红霉素的甲醇溶剂化物极为相似。
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