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[睾丸生殖细胞肿瘤的诊断与分期]

[Diagnosis and staging of germ-cell tumours of the testis].

作者信息

Mottet Nicolas, Berger Nicole, Droz Jean-Pierre

机构信息

Département d'urologie, Clinique mutualiste, Saint-Etienne.

出版信息

Rev Prat. 2007 Feb 28;57(4):365-78.

Abstract

The diagnosis of germ-cell tumour is based on the histological examination of the inguinal orchiectomy specimen. The histological classification allows discriminating seminoma and non seminomatous tumours. Non seminomatous tumours are heterogeneous, different sub-groups are described: embryonal carcinoma, teratoma, choriocarcinoma, yolk sac tumours, but components are often mixed. Serum tumour markers, human chorionic gonadotropin hormone and alpha-foetoprotein, are important as well in the initial diagnosis, the prognosis, and follow-up of the disease. The staging procedure is strict and the prognostic factors allow defining the optimal treatment according to well established guidelines. Complete information of the patient is mandatory. All consequences of the disease and treatment must be managed, the most important being sperm conservation.

摘要

生殖细胞肿瘤的诊断基于腹股沟睾丸切除术标本的组织学检查。组织学分类有助于区分精原细胞瘤和非精原细胞瘤。非精原细胞瘤具有异质性,可分为不同亚组:胚胎癌、畸胎瘤、绒毛膜癌、卵黄囊瘤,但各成分常混合存在。血清肿瘤标志物,即人绒毛膜促性腺激素和甲胎蛋白,在疾病的初始诊断、预后及随访中也很重要。分期程序严格,预后因素有助于根据既定指南确定最佳治疗方案。患者的完整信息必不可少。必须对疾病和治疗的所有后果进行处理,其中最重要的是保留精子。

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