Jarosz Patricia A
Wayne State University, College of Nursing, Detroit, Michigan 48202, USA.
Biol Res Nurs. 2007 Apr;8(4):294-9. doi: 10.1177/1099800406298774.
Food intake and, subsequently, body weight are influenced by endogenous opioids acting in the central nervous system. Agonists for the opioid receptor increase food intake, whereas antagonists reduce food intake. Body weight, however, is the result of food consumed and energy expended. Although much has been reported about the effect of opioid antagonism on food intake, less has been reported about its effect on energy expended. This study investigated the effect of selective antagonism of the kappa opioid receptor on food intake, body weight, and indicators of energy expenditure in male obese Zucker rats (n=10). Energy expenditure was measured by indirect calorimetry, whereas general activity and body temperature were measured by implanted radio frequency telemetry. Central administration of 30 microg of the kappa opioid receptor (KOR) antagonist norbinaltorphamine resulted in a significant 34% reduction in food intake (p =.001), a small reduction in body weight, a reduction in resting energy expenditure (p = .06), a reduction in respiratory quotient (p =.06), a 14% reduction in general activity, and a reduction in core body temperature. Reduction in body weight as a result of KOR inhibition in this study was related to a decrease in food intake but not related to an increase in energy expended or activity.
食物摄入量以及随后的体重受到作用于中枢神经系统的内源性阿片类物质的影响。阿片受体激动剂会增加食物摄入量，而拮抗剂则会减少食物摄入量。然而，体重是所摄入食物和消耗能量的结果。尽管关于阿片类拮抗剂对食物摄入量的影响已有大量报道，但关于其对能量消耗的影响报道较少。本研究调查了选择性拮抗κ阿片受体对雄性肥胖Zucker大鼠（n = 10）的食物摄入量、体重和能量消耗指标的影响。通过间接测热法测量能量消耗，而通过植入式射频遥测技术测量一般活动和体温。向中枢给予30微克的κ阿片受体（KOR）拮抗剂诺美沙朵，导致食物摄入量显著减少34%（p = .001），体重略有下降，静息能量消耗减少（p = .06），呼吸商降低（p = .06），一般活动减少14%，以及核心体温降低。在本研究中，由于KOR抑制导致的体重减轻与食物摄入量减少有关，但与能量消耗增加或活动增加无关。
