Coscoy Laurent
Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA.
Nat Rev Immunol. 2007 May;7(5):391-401. doi: 10.1038/nri2076.
To efficiently establish a persistent infection, Kaposi's sarcoma-associated herpesvirus (KSHV; also known as HHV8) dedicates a large amount of its coding potential to produce proteins that antagonize the immune system of its host. These viral immunomodulators interfere with both the innate and adaptive immune responses and most of them are homologous to cellular proteins, suggesting that they have been pirated from the host during viral evolution. In this Review, I present recent advances in the understanding of immune evasion by KSHV, with a particular focus on the virally encoded modulators of immune responses that are unique to this virus.
为了有效地建立持续性感染，卡波西肉瘤相关疱疹病毒（KSHV；也称为HHV8）将其大量编码潜能用于产生对抗宿主免疫系统的蛋白质。这些病毒免疫调节剂会干扰先天性和适应性免疫反应，并且它们中的大多数与细胞蛋白同源，这表明它们是在病毒进化过程中从宿主那里盗用而来的。在这篇综述中，我介绍了对KSHV免疫逃逸理解的最新进展，特别关注该病毒特有的病毒编码免疫反应调节剂。
