Chyu Kuang-Yuh, Nilsson Jan, Shah Prediman K
Cedars-Sinai Medical Center and David Geffen School of Medicine at UCLA, Division of Cardiology and Atherosclerosis Research Center, Suite 5347, 8700 Beverly Blvd., Los Angeles, CA 90048, USA.
Curr Opin Mol Ther. 2007 Apr;9(2):176-82.
This review summarizes experimental findings that highlight the role of immune mechanisms in atherosclerosis and the potential atheroprotective effects of active or passive immunization strategies. Inmmunomodulation therapy appears to be feasible and effective, suggesting that a vaccine for atherosclerosis can be developed for clinical testing. Given the increasing number of patients with atherosclerotic disease on current therapy, a new therapy is needed and an immunization strategy could provide such a possibility. Several questions regarding this approach remain unanswered, however, such as choice of optimal antigens, choice of most effective adjuvants, the optimal route of administration, durability of effects and safety, but cautious optimism remains that a vaccine-based approach has the potential to become a part of the armamentarium for atherosclerotic vascular disease.
本综述总结了一些实验结果，这些结果突出了免疫机制在动脉粥样硬化中的作用以及主动或被动免疫策略潜在的抗动脉粥样硬化作用。免疫调节疗法似乎可行且有效，这表明可以开发一种用于动脉粥样硬化的疫苗进行临床试验。鉴于目前接受治疗的动脉粥样硬化疾病患者数量不断增加，需要一种新的治疗方法，而免疫策略可能提供这样一种可能性。然而，关于这种方法仍有几个问题尚未得到解答，例如最佳抗原的选择、最有效佐剂的选择、最佳给药途径、效果的持久性和安全性，但人们仍谨慎乐观地认为，基于疫苗的方法有可能成为动脉粥样硬化性血管疾病治疗手段的一部分。
