Cholevas V, Challa A, Lapatsanis P D, Andronikou S
Research Laboratory of Child Health Department, University of Ioannina, Medical School, P.O. Box 1186, Ioannina, 451 10, Greece.
Eur J Pediatr. 2008 Feb;167(2):211-8. doi: 10.1007/s00431-007-0464-5. Epub 2007 Apr 26.
The effects of perinatal problems on red cell phosphate metabolism were studied in two groups of infants (preterms B and fullterms D) during the first month of life. All infants started milk feeding from day three after birth. The results were compared to those of healthy preterms (A) and fullterms (C), respectively. Comparisons were also made between the preterm and fullterm groups B and D. The preterms with perinatal problems (B) showed a significant delay in catching up with the plasma and red cell inorganic phosphate (Pi) levels of controls (A) throughout the first month of life (p < 0.05). In parallel, the erythrocyte 2,3 diphosphoglycerate (2,3-DPG) concentrations of the sick preterms lagged significantly behind those of controls (p < 0.001); but the ATP levels were comparable between the two groups. The fullterms behaved slightly differently. No significant differences in plasma Pi (Pl Pi) and red cell 2,3-DPG were seen between the sick and healthy neonates during the month of study, while red cell Pi (RBC Pi) and ATP were found to be lower in the sick ones (p < 0.05). The fullterms with perinatal problems (D) had significantly higher Pl Pi (p < 0.05) and RBC Pi (p < 0.01) than preterms with problems (B) from the first week of life and continued in a similar pattern until the end of the month. Red cell 2,3-DPG concentrations were found to be significantly correlated with Pl Pi and RBC Pi in both preterm groups (p < 0.01) and in the sick fullterms (p < 0.001) during the time of the study. In the healthy fullterms 2,3-DPG was found to correlate only with red cell Pi (p < 0.05). Perinatal problems seem to affect Pi metabolism to a different degree in preterm and fullterm neonates in the first month of life.
在出生后的第一个月，对两组婴儿（早产B组和足月D组）围产期问题对红细胞磷酸盐代谢的影响进行了研究。所有婴儿在出生后第三天开始喂牛奶。结果分别与健康早产儿（A组）和足月儿（C组）进行比较。同时也对早产组和足月组B和D进行了比较。有围产期问题的早产儿（B组）在出生后的第一个月内，血浆和红细胞无机磷酸盐（Pi）水平显著落后于对照组（A组）（p<0.05）。同时，患病早产儿的红细胞2,3-二磷酸甘油酸（2,3-DPG）浓度显著低于对照组（p<0.001）；但两组的ATP水平相当。足月儿的情况略有不同。在研究期间，患病新生儿和健康新生儿的血浆Pi（Pl Pi）和红细胞2,3-DPG没有显著差异，而患病新生儿的红细胞Pi（RBC Pi）和ATP较低（p<0.05）。有围产期问题的足月儿（D组）从出生第一周起，其Pl Pi（p<0.05）和RBC Pi（p<0.01）显著高于有问题的早产儿（B组），并持续到月底。在研究期间，早产组和患病足月儿组的红细胞2,3-DPG浓度与Pl Pi和RBC Pi显著相关（p<0.01）。在健康足月儿中，2,3-DPG仅与红细胞Pi相关（p<0.05）。围产期问题似乎在出生后的第一个月对早产和足月新生儿的Pi代谢有不同程度的影响。
