β-分泌酶1（BACE-1）的2,3,5-取代咪唑烷-4-酮抑制剂的设计与合成 - Suppr

Design and synthesis of 2,3,5-substituted imidazolidin-4-one inhibitors of BACE-1.

作者信息

Barrow James C, Rittle Kenneth E, Ngo Phung L, Selnick Harold G, Graham Samuel L, Pitzenberger Steven M, McGaughey Georgia B, Colussi Dennis, Lai Ming-Tain, Huang Qian, Tugusheva Katherine, Espeseth Amy S, Simon Adam J, Munshi Sanjeev K, Vacca Joseph P

机构信息

Department of Medicinal Chemistry, Merck Research Laboratories, P.O Box 4, WP14-1, West Point, PA 19486, USA.

出版信息

ChemMedChem. 2007 Jul;2(7):995-9. doi: 10.1002/cmdc.200700038.

DOI:10.1002/cmdc.200700038

PMID:17458843

Abstract

摘要

相似文献

Design and synthesis of 2,3,5-substituted imidazolidin-4-one inhibitors of BACE-1.

ChemMedChem. 2007 Jul;2(7):995-9. doi: 10.1002/cmdc.200700038.

Potent pyrrolidine- and piperidine-based BACE-1 inhibitors.

Bioorg Med Chem Lett. 2008 Jan 1;18(1):414-7. doi: 10.1016/j.bmcl.2007.10.116. Epub 2007 Nov 6.

Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: structure-activity relationship of the aryl region.

Bioorg Med Chem Lett. 2010 Oct 15;20(20):6034-9. doi: 10.1016/j.bmcl.2010.08.070. Epub 2010 Aug 19.

Discovery of an orally efficaceous 4-phenoxypyrrolidine-based BACE-1 inhibitor.

Bioorg Med Chem Lett. 2008 Jan 1;18(1):418-22. doi: 10.1016/j.bmcl.2007.10.053. Epub 2007 Oct 18.

Design, synthesis and SAR of potent statine-based BACE-1 inhibitors: exploration of P1 phenoxy and benzyloxy residues.

Bioorg Med Chem. 2008 Nov 1;16(21):9471-86. doi: 10.1016/j.bmc.2008.09.041. Epub 2008 Sep 19.

Structure-based design and synthesis of macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors.

Bioorg Med Chem Lett. 2009 Mar 1;19(5):1361-5. doi: 10.1016/j.bmcl.2009.01.036. Epub 2009 Jan 19.

Discovery and X-ray crystallographic analysis of a spiropiperidine iminohydantoin inhibitor of beta-secretase.

J Med Chem. 2008 Oct 23;51(20):6259-62. doi: 10.1021/jm800914n. Epub 2008 Sep 24.

Design and synthesis of potent and selective BACE-1 inhibitors.

J Med Chem. 2010 Feb 25;53(4):1458-64. doi: 10.1021/jm901168f.

Rational design of novel, potent piperazinone and imidazolidinone BACE1 inhibitors.

Bioorg Med Chem Lett. 2008 Jun 1;18(11):3236-41. doi: 10.1016/j.bmcl.2008.04.050. Epub 2008 Apr 25.

Design, synthesis, and SAR of macrocyclic tertiary carbinamine BACE-1 inhibitors.

Bioorg Med Chem Lett. 2007 Jul 15;17(14):4057-61. doi: 10.1016/j.bmcl.2007.04.072. Epub 2007 Apr 27.

引用本文的文献

Reaction of Picolinamides with Ketones Producing a New Type of Heterocyclic Salts with an Imidazolidin-4-One Ring.

Molecules. 2023 Dec 29;29(1):206. doi: 10.3390/molecules29010206.

Crystal structure, Hirshfeld surface analysis and PIXEL calculations of a 1:1 epimeric mixture of 3-[(4-nitro-benzyl-idene)amino]-2()-(4-nitro-phenyl)-5()-(propan-2-yl)imidazolidin-4-one.

Acta Crystallogr E Crystallogr Commun. 2019 Oct 29;75(Pt 11):1774-1782. doi: 10.1107/S2056989019013938. eCollection 2019 Nov 1.

BACE1 (β-secretase) inhibitors for the treatment of Alzheimer's disease.

Chem Soc Rev. 2014 Oct 7;43(19):6765-813. doi: 10.1039/c3cs60460h.

Virtual screening and structure-based discovery of indole acylguanidines as potent β-secretase (BACE1) inhibitors.

Molecules. 2013 May 16;18(5):5706-22. doi: 10.3390/molecules18055706.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验

Design and synthesis of 2,3,5-substituted imidazolidin-4-one inhibitors of BACE-1.

作者信息

机构信息

出版信息

相似文献

引用本文的文献

文献AI研究员

用中文搜PubMed

文档翻译

Suppr 超能文献

相似文献

引用本文的文献