利用近红外荧光对脑积水小鼠的脑脊液空间和流动进行成像。

Imaging of cerebrospinal fluid space and movement of hydrocephalus mice using near infrared fluorescence.

作者信息

Shibata Y, Kruskal J B, Palmer M R

机构信息

Department of Neurosurgery Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.

出版信息

Neurol Sci. 2007 Apr;28(2):87-92. doi: 10.1007/s10072-007-0792-2.

DOI:10.1007/s10072-007-0792-2

PMID:17464471

Abstract

We have studied optical imaging of mice cerebrospinal fluid (CSF) space and flow using near infrared (NIR) fluorescence. We applied our method to image CSF space and flow in a mice hydrocephalus model. Hydrocephalus was induced in mice with intracranial injections of transforming growth factor. Hydrocephalic and control mice were imaged using our NIR fluorescence imaging system. Hydrocephalic mice showed diminished intracranial CSF flow. Our system is sufficient to show altered CSF flow in a mouse hydrocephalus model. Optical imaging using near infrared is an effective modality to image CSF space and movement.

摘要

我们利用近红外（NIR）荧光研究了小鼠脑脊液（CSF）空间和流动的光学成像。我们将我们的方法应用于小鼠脑积水模型中脑脊液空间和流动的成像。通过向小鼠颅内注射转化生长因子诱导脑积水。使用我们的近红外荧光成像系统对脑积水小鼠和对照小鼠进行成像。脑积水小鼠的颅内脑脊液流动减少。我们的系统足以显示小鼠脑积水模型中脑脊液流动的改变。利用近红外进行光学成像是对脑脊液空间和运动进行成像的有效方式。