Bedalov Goran, Bartolin Zeljko, Puskar Damir, Savić Ivan, Bedalov Ivana, Rudolf Marija, Batinić Drago
Department of Urology, University Hospital Dubrava, Avenija Gojka Suska 6, 10000, Zagreb, Croatia.
Lasers Med Sci. 2008 Jan;23(1):65-70. doi: 10.1007/s10103-007-0462-x. Epub 2007 Apr 28.
The objective of the study was to determine the differences in systemic stress response in patients undergoing transurethral resection of the prostate (TURP) versus endoscopic laser ablation of the prostate (ELAP) for benign prostatic hyperplasia (BPH). The study included 48 patients with BPH (24 treated by TURP and 24 by ELAP). Blood samples were taken from each patient before and immediately after the procedure and on postoperative days 1, 6, and 20, respectively. TURP caused more intense acute-phase response during 24 h after the procedure considering the serum c-reactive protein (CRP) level (p < 0,001) and absolute leukocyte (p = 0.001) and neutrophil number (p = 0.003) in peripheral blood. ELAP caused more decrease in the number of natural killer cells immediately after the procedure (p = 0.048). There were no statistically significant differences between TURP and ELAP procedures in protein and creatine kinase (CK) levels, adrenocorticotropic hormone, and cortisol as well as other immunological parameters. TURP causes more intense acute-phase response than ELAP.
本研究的目的是确定接受经尿道前列腺切除术（TURP）与内镜下前列腺激光消融术（ELAP）治疗良性前列腺增生（BPH）的患者全身应激反应的差异。该研究纳入了48例BPH患者（24例接受TURP治疗，24例接受ELAP治疗）。分别在术前、术后即刻以及术后第1天、第6天和第20天采集每位患者的血样。考虑到血清C反应蛋白（CRP）水平（p<0.001）、外周血中白细胞绝对值（p=0.001）和中性粒细胞数量（p=0.003），TURP在术后24小时内引起更强烈的急性期反应。ELAP在术后即刻导致自然杀伤细胞数量下降更多（p=0.048）。在蛋白质和肌酸激酶（CK）水平、促肾上腺皮质激素和皮质醇以及其他免疫参数方面，TURP和ELAP手术之间没有统计学上的显著差异。TURP比ELAP引起更强烈的急性期反应。
