Donald Colin, Duncan Russell, Blair Lorraine, Thakore Shobhan, Clark Michael
Accident and Emergency, Ninewells Hospital, Dundee, Scotland, UK.
Eur J Emerg Med. 2007 Jun;14(3):157-9. doi: 10.1097/MEJ.0b013e3280b17e36.
To measure the dose discrepancy in prescribing simple paediatric analgesia, in the emergency department, by comparing age and actual weight-based dosing. To establish the accuracy of the weight-estimation formula for children [weight kg=2 (age years+4)].
A prospective survey conducted in the emergency departments of a UK teaching hospital and district general hospital. Two hundred and forty-seven children were prescribed simple analgesia in the form of paracetamol and ibuprofen or both. The dose prescribed was based on age. All children were weighed and a maximum dose based on the child's weight was calculated. The individual child's weight was also compared with the weight calculated using the estimation formula.
A total of 247 patients were included. Two hundred and thirty-three patients were prescribed paracetamol. Fifteen patients were prescribed ibuprofen. The paracetamol group was administered a mean dose that was 67% (P<0.001) of the optimal dose that was based on weight. Ibuprofen dosage was 51% (P<0.001) of optimal dose. The weight-estimation formula underestimated weight by 16% (P<0.001).
Prescribing analgesia by age often results in significant underdosing in the paediatric population. Predicting a child's weight using the calculation may result in underdosing.
通过比较基于年龄和实际体重的给药剂量,测量急诊科开具简单儿科镇痛药物时的剂量差异。确定儿童体重估算公式[体重(千克)=2×(年龄+4)]的准确性。
在英国一家教学医院和地区综合医院的急诊科进行一项前瞻性调查。247名儿童接受了对乙酰氨基酚和布洛芬形式的简单镇痛治疗,或两者皆用。所开剂量基于年龄。对所有儿童进行称重,并计算基于儿童体重的最大剂量。还将每个儿童的体重与使用估算公式计算出的体重进行比较。
共纳入247例患者。233例患者接受了对乙酰氨基酚治疗。15例患者接受了布洛芬治疗。对乙酰氨基酚组的平均给药剂量为基于体重的最佳剂量的67%(P<0.001)。布洛芬剂量为最佳剂量的51%(P<0.001)。体重估算公式使体重低估了16%(P<0.001)。
按年龄开具镇痛药物常常导致儿科患者用药剂量显著不足。使用该计算公式预测儿童体重可能导致用药剂量不足。