剂型中头孢西丁钠的微生物学测定法。
Microbiological assay for cefoxitin sodium in dosage form.
作者信息
Salgado Hérida Regina Nunes, Tozo Greici Cristiani Gomes
机构信息
Faculdade de Ciências Farmacêuticas, Programa de Pós-graduação em Ciências Farmacêuticas, UNESP, Rod. Araraquara-Jaú, km 1, CEP 14801-902, Araraquara, SP, Brazil.
出版信息
J AOAC Int. 2007 Mar-Apr;90(2):452-5.
A microbiological assay applying the cylinder-plate method is described for determination of the activity of cefoxitin sodium in injectables. Using a strain of Staphylococcus epidermidis ATCC 12226 as the test organism, cefoxitin sodium was measured in concentrations ranging from 50.0 to 200.0 microg/mL. The validation showed that the method was linear (r = 0.9998), precise (RSD = 0.81%), and accurate. It was concluded that the microbiological assay is satisfactory for quantitation of cefoxitin sodium in injectables.
描述了一种采用圆筒平板法的微生物测定法，用于测定注射用头孢西丁钠的活性。以表皮葡萄球菌ATCC 12226菌株作为测试菌，测定头孢西丁钠的浓度范围为50.0至200.0微克/毫升。验证表明该方法具有线性（r = 0.9998）、精密度（RSD = 0.81%）和准确性。得出结论，该微生物测定法可用于注射用头孢西丁钠的定量分析，结果令人满意。
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