Catalano F, Mangiameli A, Inserra G, Monello S, Brogna A, Sofia M, Rizzo G, Ayoubi Khajekini M, Blasi A
Istituto di I Patologia Medica dell'Università di Catania, Italy.
Ital J Gastroenterol. 1991 Jan;23(1):9-11.
Forty-three patients with active duodenal ulcer and Helicobacter pylori positivity in gastric antrum were randomly assigned to either omeprazole treatment (20 mg once a day) or ranitidine treatment (300 mg once a day) for 28 days. Re-evaluation of the patients (clinical and endoscopic examination and assessments for H pylori detection) was repeated after 2 weeks and at the end of the treatment. Healing rates in the omeprazole group were 40% after 2 weeks and 90% after 4 weeks, in the ranitidine group ulcer healing was recorded in 20% of patients after 2 weeks and in 80% after 4 weeks. Differences between treatments at 2 and 4 weeks were not statistically significant. Clinical response (disappearance of ulcer-related symptoms) was better in the omeprazole group at 2 weeks (p less than 0.05) but not at 4 weeks. At the end of the trial H pylori positivity in gastric antrum disappeared in 95% of the patients treated with omeprazole and in 5% of the patients who received ranitidine (p less than 0.001). The results confirm the effectiveness of omeprazole in short-term treatment of duodenal ulcer and re-emphasize the powerful activity of the drug on H pylori infection.
43例患有活动性十二指肠溃疡且胃窦幽门螺杆菌阳性的患者被随机分为两组，分别接受奥美拉唑治疗（每日1次，每次20mg）或雷尼替丁治疗（每日1次，每次300mg），疗程为28天。在2周后以及治疗结束时对患者进行重新评估（临床及内镜检查，并评估幽门螺杆菌检测结果）。奥美拉唑组2周后的愈合率为40%，4周后为90%；雷尼替丁组2周后20%的患者溃疡愈合，4周后为80%。2周和4周时治疗组之间的差异无统计学意义。奥美拉唑组在2周时临床反应（溃疡相关症状消失）更好（p<0.05），但4周时并非如此。试验结束时，奥美拉唑治疗的患者中95%胃窦幽门螺杆菌阳性消失，接受雷尼替丁治疗的患者中这一比例为5%（p<0.001）。结果证实了奥美拉唑在十二指肠溃疡短期治疗中的有效性，并再次强调了该药物对幽门螺杆菌感染的强大作用。
