Vodná Lucia, Bubeníková Silvia, Lacík Igor, Chorvát Dusan, Bakos Dusan
Department of Plastics and Rubber, Faculty of Chemical and Food Technology, Slovak Technical University, Radlinského 9, Bratislava, Slovak Republic.
Macromol Biosci. 2007 May 10;7(5):629-34. doi: 10.1002/mabi.200600290.
Chitosan/tripolyphosphate (CHIT/TPP) and chitosan/tripolyphosphate/chondroitin sulfate (CHIT/TPP/CHS) core-shell type microspheres were prepared by polyelectrolyte complexation in order to develop a biocompatible matrix for drug delivery. The continual method using a multi-loop reactor under sterile conditions was applied for microsphere preparation. All the types of microspheres produced were spherical in shape and had a porous structure. The mechanical resistance of the microspheres increased in the presence of CHS as the second polyanion, which toughened the microsphere shell structure. For a drug release application, the process of microsphere preparation was modified by dissolving ofloxacin (OFL), the fluoroquinolone antibiotic, in CHIT solution before complex formation. This study shows the difference in OFL release comparing the microspheres CHIT/TPP and CHIT/TPP/CHS and implies the potential to control this process.
为了开发一种用于药物递送的生物相容性基质，通过聚电解质络合制备了壳聚糖/三聚磷酸钠（CHIT/TPP）和壳聚糖/三聚磷酸钠/硫酸软骨素（CHIT/TPP/CHS）核壳型微球。在无菌条件下使用多环反应器的连续方法用于微球制备。所制备的所有类型微球均呈球形且具有多孔结构。作为第二种聚阴离子，CHS的存在增加了微球的机械抗性，从而强化了微球壳结构。对于药物释放应用，在形成络合物之前，通过将氟喹诺酮抗生素氧氟沙星（OFL）溶解在CHIT溶液中来改进微球制备过程。本研究显示了CHIT/TPP和CHIT/TPP/CHS微球在OFL释放方面的差异，并暗示了控制该过程的潜力。
