上皮性卵巢癌的异质性：调和新旧范式。

The heterogeneity of epithelial ovarian cancers: reconciling old and new paradigms.

作者信息

Naora Honami

机构信息

University of Texas M.D. Anderson Cancer Center, Department of Molecular Therapeutics, Unit 950, 7435 Fannin Street, South Campus Research Building II, Room 3.2028, Houston, TX 77054, USA.

出版信息

Expert Rev Mol Med. 2007 May 4;9(13):1-12. doi: 10.1017/S1462399407000324.

DOI:10.1017/S1462399407000324

PMID:17477890

Abstract

Epithelial ovarian cancer comprises several subtypes of tumours that exhibit diverse histopathological features. The intriguing assumption by many epithelial ovarian cancers of specialised features of nonovarian tissue lineages has promoted considerable debate as to whether these tumours arise from the deceptively simple surface epithelium of the ovary. This review focuses on recent molecular and pathological studies of epithelial ovarian cancers that support and challenge their surface-epithelial derivation, and discusses the findings in the context of current views of the 'cell-of-origin' of solid tumours.

摘要

上皮性卵巢癌由几种具有不同组织病理学特征的肿瘤亚型组成。许多上皮性卵巢癌具有非卵巢组织谱系的特殊特征，这一有趣的假设引发了关于这些肿瘤是否起源于看似简单的卵巢表面上皮的大量争论。本综述重点关注支持和质疑上皮性卵巢癌表面上皮起源的近期分子和病理学研究，并在实体瘤“起源细胞”的当前观点背景下讨论这些发现。