Pierzynski Piotr, Reinheimer Torsten M, Kuczynski Waldemar
Center for Reproductive Medicine KRIOBANK, Bialystok, Poland.
Fertil Steril. 2007 Jul;88(1):213.e19-22. doi: 10.1016/j.fertnstert.2006.09.017. Epub 2007 May 3.
To confirm the improvement of uterine receptivity following administration of oxytocin and vasopressin V1A antagonist atosiban.
Case report.
Private reproductive medicine center.
PATIENT(S): A 42-year-old woman with a history of 15 years' infertility and seven failed in vitro fertilization/embryo transfer (IVF-ET) attempts.
INTERVENTION(S): Atosiban (mixed vasopressin V1A/oxytocin antagonist registered for the treatment of imminent premature birth) was administered on the 14th day of endometrial synchronization for oocyte donation.
MAIN OUTCOME MEASURE(S): Uterine contractile activity (component of uterine receptivity) and success of treatment of infertility.
RESULT(S): Intense spontaneous uterine contractility was visualized by transvaginal sonography. After 1 hour of intravenous infusion of atosiban, a repeated scan showed a significant decrease in contractile activity (11 vs 7 contractions per 4 minutes, respectively). The ET was performed immediately after, and the infusion of atosiban continued for the next 2 hours. The treatment decreased the uterine contractile activity and resulted in successful embryo implantation and a normal twin diamniotic pregnancy.
CONCLUSION(S): Atosiban may improve uterine receptivity during ET and may increase success rates of advanced infertility treatment procedures.
证实给予缩宫素和血管加压素V1A拮抗剂阿托西班后子宫容受性的改善情况。
病例报告。
私立生殖医学中心。
一名42岁女性，有15年不孕史，体外受精/胚胎移植（IVF-ET）尝试失败7次。
在进行卵母细胞捐赠的子宫内膜同步化第14天给予阿托西班（一种用于治疗即将早产的混合血管加压素V1A/缩宫素拮抗剂）。
子宫收缩活动（子宫容受性的组成部分）和不孕治疗的成功率。
经阴道超声检查可见强烈的子宫自发收缩。静脉输注阿托西班1小时后，再次扫描显示收缩活动显著降低（分别为每4分钟11次和7次收缩）。之后立即进行胚胎移植，阿托西班输注持续2小时。该治疗降低了子宫收缩活动，导致胚胎成功着床并实现了正常的双羊膜囊妊娠。
阿托西班可能在胚胎移植期间改善子宫容受性，并可能提高晚期不孕治疗程序的成功率。
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