Torres-Cartas S, Martín-Biosca Y, Villanueva-Camañas R M, Sagrado S, Medina-Hernández M J
Departamento de Química Analítica, Universidad de Valencia, C/Vicente Andrés Estellés s/n, 46100 Burjassot, Valencia, Spain.
Eur J Med Chem. 2007 Nov-Dec;42(11-12):1396-402. doi: 10.1016/j.ejmech.2007.02.022. Epub 2007 Mar 18.
Mutagenicity is a toxicity endpoint associated with the chronic exposure to chemicals. Aromatic amines have considerable industrial and environmental importance due to their widespread use in industry and their mutagenic capacity. Biopartitioning micellar chromatography (BMC), a mode of micellar liquid chromatography that uses micellar mobile phases of Brij35 in adequate experimental conditions, has demonstrated to be useful in mimicking the drug partitioning process into biological systems. In this paper, the usefulness of BMC for predicting mutagenicity of aromatic amines is demonstrated. A multiple linear regression (MLR) model based on BMC retention data is proposed and compared with other ones reported in bibliography. The proposed model present better or similar descriptive and predictive capability.
致突变性是与长期接触化学物质相关的毒性终点。芳香胺由于在工业中的广泛应用及其致突变能力，在工业和环境方面具有相当重要的意义。生物分配胶束色谱法（BMC）是一种胶束液相色谱模式，在适当的实验条件下使用Brij35的胶束流动相，已证明可用于模拟药物在生物系统中的分配过程。本文证明了BMC在预测芳香胺致突变性方面的实用性。提出了一种基于BMC保留数据的多元线性回归（MLR）模型，并与文献中报道的其他模型进行了比较。所提出的模型具有更好或相似的描述和预测能力。
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