O6-烷基鸟嘌呤-DNA烷基转移酶的人类变体
Human variants of O6-alkylguanine-DNA alkyltransferase.
作者信息
Pegg Anthony E, Fang Qingming, Loktionova Natalia A
机构信息
Department of Cellular and Molecular Physiology, Milton S. Hershey Medical Center, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA.
出版信息
DNA Repair (Amst). 2007 Aug 1;6(8):1071-8. doi: 10.1016/j.dnarep.2007.03.012. Epub 2007 May 7.
Abstract
This article summarizes the current understanding of known variant forms of the MGMT gene that encode an altered protein. Epidemiological studies have been carried out to test whether these alterations are associated with altered cancer risk. Laboratory studies using recombinant proteins and cells expressing the known variants have investigated the possible effects of these sequence alterations on the ability of the encoded O(6)-alkylguanine-DNA alkyltransferase protein to protect cells from alkylation damage and to respond to therapeutic inactivators currently undergoing trials for cancer chemotherapy.
摘要
本文总结了目前对编码改变蛋白的MGMT基因已知变异形式的理解。已经开展了流行病学研究，以测试这些改变是否与癌症风险改变相关。使用重组蛋白和表达已知变体的细胞进行的实验室研究，调查了这些序列改变对编码的O(6)-烷基鸟嘌呤-DNA烷基转移酶蛋白保护细胞免受烷基化损伤以及对目前正在进行癌症化疗试验的治疗性失活剂作出反应的能力的可能影响。
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