Michaud Dominique S
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.
Urol Oncol. 2007 May-Jun;25(3):260-8. doi: 10.1016/j.urolonc.2006.10.002.
The relation between Schistosomiasis and bladder cancer is well-established and accounts for the high rates of bladder cancer in a number of developing countries, including Egypt. In developed countries, transitional cell carcinoma is the predominant type of bladder cancer, whereas in Schistosomiasis-endemic regions, squamous cell carcinoma is the most common type. In this review, experimental and observational data on infection, inflammation, and bladder cancer are summarized with special emphasis on transitional cell carcinoma. Findings from numerous studies suggest that inflammation is likely to have an important role in bladder carcinogenesis in developed countries. Future studies need to focus in greater detail on risk factors that increase inflammation of the bladder, examine genetic susceptibility to inflammatory pathways, and include markers of inflammation measured prior to cancer diagnosis. Understanding the role of inflammation on transitional cell carcinogenesis may provide important insights on how to prevent the sixth most common cancer in the United States.
血吸虫病与膀胱癌之间的关系已得到充分证实，这也是包括埃及在内的一些发展中国家膀胱癌发病率居高不下的原因。在发达国家，移行细胞癌是膀胱癌的主要类型，而在血吸虫病流行地区，鳞状细胞癌是最常见的类型。在本综述中，我们总结了关于感染、炎症和膀胱癌的实验及观察数据，特别强调了移行细胞癌。众多研究结果表明，在发达国家，炎症可能在膀胱癌的致癌过程中发挥重要作用。未来的研究需要更详细地关注增加膀胱炎症的危险因素，研究炎症途径的遗传易感性，并纳入癌症诊断前测量的炎症标志物。了解炎症在移行细胞癌发生中的作用，可能为预防美国第六大常见癌症提供重要见解。
