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血管内主动脉瘤修复术后的肾功能:经肾与肾下固定的单中心经验

Renal function after endovascular aortic aneurysm repair: a single-center experience with transrenal versus infrarenal fixation.

作者信息

Waasdorp Evert, van't Hullenaar Casper, van Herwaarden Joost, Kelder Hans, van de Pavoordt Eric, Overtoom Tim, Moll Frans, de Vries Jean-Paul

机构信息

Department of Vascular Surgery, St. Antonius Hospital, Nieuwegein, The Netherlands.

出版信息

J Endovasc Ther. 2007 Apr;14(2):130-7. doi: 10.1177/152660280701400203.

Abstract

PURPOSE

To describe the short-term consequences of endovascular aortic aneurysm repair (EVAR) on renal function after infrarenal (IR) versus transrenal (TR) stent-graft fixation.

METHODS

Between December 1996 and January 2006, 369 consecutive patients were treated with EVAR. All patients had an AneuRx or a Talent stent-graft implanted using IR (AneuRx) or transrenal (Talent) fixation. Post-EVAR, a standardized follow-up scheme included computed tomography (CT) scanning and serum creatinine measurements at 2 days, 3 months, and 12 months. Postoperative renal dysfunction was defined as a >20% decrease in serum creatinine clearance compared to baseline, the presence of new-onset dialysis, or both. Of the 369 patients, 309 (291 men; mean age 71+/-7 years, range 63-82) had complete 1-year follow-up and were included in this study. An IR stent-graft was placed in 190 patients, and a TR stent-graft was placed in the remaining 119 patients.

RESULTS

At discharge, renal dysfunction occurred in 3.7% of the patients in the IR group versus 5.9% in the TR group (p = NS) and rose significantly to 13.7% in the IR group (p = 0.001) and 15.1% in the TR group (p = 0.02) at the 1-year follow-up. However, no significant difference was noted between the IR and TR groups at either time point. At the 1-year follow-up, at least 50% of renal dysfunction was caused by obstructions of (accessory) renal arteries and renal infarctions. During the follow-up interval, 3 (0.97%) of 309 patients underwent new-onset dialysis.

CONCLUSION

Both infrarenal and transrenal fixation techniques in EVAR will lead to a significant rise in renal dysfunction during the first year. A few patients with dysfunction will require dialysis.

摘要

目的

描述肾下(IR)与经肾(TR)支架移植物固定术后,血管内主动脉瘤修复术(EVAR)对肾功能的短期影响。

方法

1996年12月至2006年1月期间,连续369例患者接受了EVAR治疗。所有患者均使用IR(AneuRx)或经肾(Talent)固定方式植入了AneuRx或Talent支架移植物。EVAR术后,标准化的随访方案包括在术后2天、3个月和12个月进行计算机断层扫描(CT)和血清肌酐测量。术后肾功能不全定义为血清肌酐清除率较基线下降>20%、出现新发透析或两者兼有。369例患者中,309例(291例男性;平均年龄71±7岁,范围63 - 82岁)进行了完整的1年随访并纳入本研究。190例患者植入了IR支架移植物,其余119例患者植入了TR支架移植物。

结果

出院时,IR组3.7%的患者出现肾功能不全,TR组为5.9%(p = 无显著差异),1年随访时,IR组显著升至13.7%(p = 0.001),TR组为15.1%(p = 0.02)。然而,两个时间点IR组和TR组之间均未发现显著差异。1年随访时,至少50%的肾功能不全是由(副)肾动脉阻塞和肾梗死引起的。在随访期间,309例患者中有3例(0.97%)接受了新发透析。

结论

EVAR中的肾下和经肾固定技术在第一年都会导致肾功能不全显著增加。少数功能不全患者需要透析。

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