喂食缺乏维生素D饮食的怀孕大鼠的钙代谢

Calcium metabolism of pregnant rats fed a vitamin D-depleted diet.

作者信息

Yamagishi Norio, Sassa Hiromi, Sato Reeko, Taniguchi Kazuyuki, Okura Norimoto, Sato Shigeru, Naito Yoshihisa

机构信息

Department of Clinical Veterinary Medicine, Faculty of Agriculture, Iwate University, Morioka, Japan.

出版信息

J Vet Med Sci. 2007 Apr;69(4):441-3. doi: 10.1292/jvms.69.441.

DOI:10.1292/jvms.69.441

PMID:17485938

Abstract

The effects of vitamin D (VD) deficiency on calcium (Ca) metabolism during pregnancy were evaluated in rats fed VD-repleted (VD-repleted rats) and VD-depleted (VD-depleted rats) diets. In the VD-depleted rats, the plasma concentrations of 1,25-dihydroxyvitamin D and Ca decreased severely, whereas the parathyroid hormone concentrations increased. The Ca contents of the feces of the VD-depleted rats were higher than those of the VD-repleted rats. The fetal Ca contents of the VD-repleted and VD-depleted rats increased continuously, but that of the VD-depleted rats was lower. These data reveal that VD deficiency during pregnancy induces severe hypocalcemia due to reduced intestinal absorption of Ca and elevated fetal demand for Ca.

摘要

在喂食充足维生素D（VD充足大鼠）和缺乏维生素D（VD缺乏大鼠）饮食的大鼠中，评估了孕期维生素D（VD）缺乏对钙（Ca）代谢的影响。在VD缺乏大鼠中，1,25 - 二羟基维生素D和钙的血浆浓度严重降低，而甲状旁腺激素浓度升高。VD缺乏大鼠粪便中的钙含量高于VD充足大鼠。VD充足和VD缺乏大鼠的胎儿钙含量均持续增加，但VD缺乏大鼠的胎儿钙含量较低。这些数据表明，孕期VD缺乏会因肠道钙吸收减少和胎儿对钙的需求增加而导致严重低钙血症。