C-type natriuretic peptide in individuals with normal left ventricular systolic function.

作者信息

Kuo Jen-Yuan, Yeh Hung-I, Chang Sheng-Hsiung, Shih Bing-Fu, Wang An-Mei, Chen Chun-Yen, Hou Charles Jia-Yin

机构信息

Division of Cardiology, Department of Internal Medicine, Mackay Memorial Hospital, Mackay Medicine, Nursing, and Management College, and National Yang-Ming University, School of Medicine, Taipei, Taiwan.

出版信息

Scand Cardiovasc J. 2007 Jun;41(3):155-9. doi: 10.1080/14017430701302482.

DOI:10.1080/14017430701302482

PMID:17487764

Abstract

OBJECTIVE

The objective of this study was to evaluate production or release of CNP in individuals without CHF.

METHODS

Nineteen patients with symptomatic paroxysmal supraventricular tachycardia (PSVT) and normal left ventricular systolic function were enrolled into the study. Blood samples were collected from the coronary sinus (CS), the femoral artery (FA), and the peripheral vein (PV) before pacing, after rapid RA pacing, and post electrophysiological study (EPS) and/or radiofrequency (RF) ablation.

RESULTS

The CNP level in the CS, compared to FA and PV, was significantly higher before pacing (CS, 3.2+/-0.8; FA, 2.6+/-0.7; PV, 2.5+/-0.5 pg/ml; CS vs. either FA or PV, both p<0.001), after the pacing (CS, 3.2+/-1.3; FA, 2.4+/-0.6 pg/ml; p=0.004), and post the EPS and/or RF ablation (CS, 3.1+/-0.7; FA, 2.6+/-0.9; PV, 2.5+/-0.8 pg/ml; CS vs. either FA or PV, both p<0.01).

CONCLUSION

The myocardium regularly produces or releases CNP in patients with normal LV systolic function. Brief periods of rapid RA pacing, PSVT, or EPS does not change the production and/or release.

摘要