Turturro Francesco, Driscoll Michael, Friday Ellen, Welbourne Tomas
Haematologica. 2007 May;92(5):706-7. doi: 10.3324/haematol.10923.
In this study we investigated the relevance of the oncogenic protein NPM-ALK in regulating cellular pH (pHi) through the modulation of Na+/H+ exchanger 1 (NHE1)-activity and the consequences of pHi pharmacological manipulation in cells expressing NPM-ALK.
在本研究中,我们研究了致癌蛋白NPM-ALK通过调节钠氢交换体1(NHE1)活性来调控细胞内pH值(pHi)的相关性,以及在表达NPM-ALK的细胞中进行pHi药理学调控的后果。