Jolliffe Colette T, Leece Elizabeth A, Adams Vicki, Marlin David J
Centre for Small Animal Studies, Animal Health Trust, Newmarket, UK.
Vet Anaesth Analg. 2007 Sep;34(5):322-30. doi: 10.1111/j.1467-2995.2006.00330.x. Epub 2007 May 8.
To evaluate the effect of intravenous lidocaine on coughing and variations in heart rate (HR) and systolic arterial pressure (SAP) at endotracheal intubation in propofol-anaesthetized dogs.
Prospective, randomized, blinded clinical study.
Eighty dogs, ASA grades I/II.
Dogs were randomly assigned to one of two treatments, with dogs in the lidocaine group receiving 1 mg kg(-1) lidocaine intravenously and those in the saline group receiving 0.05 mL kg(-1) saline intravenously before induction of anaesthesia with up to 6.5 mg kg(-1) propofol intravenously. An electrocardiogram was recorded continuously. Heart rate was calculated and SAP (using Doppler ultrasonic flow detection) was recorded at the following time points: pre-treatment, following lidocaine or saline administration, before and after intubation. The occurrence, number and strength of coughs were recorded. Systolic arterial pressure and HR were compared using one-sample t-tests to examine whether SAP and HR changed with test drug administration or following intubation. The number of coughs was compared between groups using t-tests. A cross tabulation and chi-square or Fisher's exact test was used to compare proportions of dogs that coughed and intensity of coughing in each group. The level of significance was set at p < 0.05.
Heart rate did not change in either group. Systolic arterial blood pressure increased following intubation in both the lidocaine (p = 0.003) and saline groups (p = 0.001). There was no difference in the increase in SAP or in the number or intensity of coughs at intubation between groups.
Intravenous lidocaine had no effect on the occurrence or intensity of coughing or on changes in SAP at endotracheal intubation in dogs anaesthetized with propofol. The use of 1 mg kg(-1) lidocaine intravenously before intubation in dogs to attenuate cough and the pressor response was not supported.
评估静脉注射利多卡因对丙泊酚麻醉犬气管插管时咳嗽及心率（HR）和收缩压（SAP）变化的影响。
前瞻性、随机、盲法临床研究。
80只美国麻醉医师协会（ASA）I/II级犬。
犬被随机分为两种治疗组之一，利多卡因组犬在静脉注射高达6.5mg/kg丙泊酚诱导麻醉前静脉注射1mg/kg利多卡因，生理盐水组犬静脉注射0.05mL/kg生理盐水。持续记录心电图。在以下时间点计算心率并记录SAP（使用多普勒超声血流检测）：治疗前、利多卡因或生理盐水给药后、插管前后。记录咳嗽的发生情况、次数和强度。使用单样本t检验比较收缩压和心率，以检查SAP和HR是否随试验药物给药或插管后发生变化。使用t检验比较组间咳嗽次数。使用交叉表和卡方检验或Fisher精确检验比较每组咳嗽犬的比例和咳嗽强度。显著性水平设定为p<0.05。
两组心率均无变化。利多卡因组（p=0.003）和生理盐水组（p=0.001）插管后收缩动脉血压均升高。两组间插管时SAP升高幅度或咳嗽次数及强度无差异。
静脉注射利多卡因对丙泊酚麻醉犬气管插管时咳嗽的发生或强度以及SAP变化无影响。不支持在犬插管前静脉注射1mg/kg利多卡因以减轻咳嗽和升压反应。
