Fortin A, Abel L, Casanova J L, Gros P
Emerillon Therapeutics, Montréal, Canada.
Annu Rev Genomics Hum Genet. 2007;8:163-92. doi: 10.1146/annurev.genom.8.080706.092315.
In humans, genetic factors have long been suspected to contribute to the onset and outcome of tuberculosis. Such effects are difficult to identify owing to their complex inheritance, and to the confounding impact of environmental factors, notably pathogen-associated virulence determinants. Recently, forward genetic approaches in mouse models and in human populations have been used to elucidate a molecular basis for predisposition to mycobacterial diseases. The genetic dissection of host predisposition to infection with Mycobacterium bovis BCG and M. tuberculosis will help to define the key molecules involved in host antituberculous immunity and should provide new insights into this important infectious disease.
长期以来，人们一直怀疑遗传因素在人类结核病的发病和转归中起作用。由于其复杂的遗传方式以及环境因素（尤其是病原体相关毒力决定因素）的混杂影响，此类效应难以确定。最近，小鼠模型和人群中的正向遗传学方法已被用于阐明易患分枝杆菌病的分子基础。对宿主易感染牛分枝杆菌卡介苗和结核分枝杆菌的遗传剖析，将有助于确定宿主抗结核免疫中涉及的关键分子，并应为这一重要传染病提供新的见解。
