通过闭环复分解途径由1α-羟基-5,6-反式维生素D3合成γ-和δ-内酯及其用金属氢化物还原
Synthesis of gamma- and delta-lactones from 1alpha-hydroxy-5,6-trans-vitamin D3 by ring-closing metathesis route and their reduction with metal hydrides.
作者信息
Wojtkielewicz Agnieszka, Morzycki Jacek W
机构信息
Institute of Chemistry, University of Bialystok, Al. Pilsudskiego 11/4, 15-443 Bialystok, Poland.
出版信息
Steroids. 2007 Jun;72(6-7):552-8. doi: 10.1016/j.steroids.2007.03.005. Epub 2007 Mar 18.
Abstract
New synthetic pathway towards 19-functionalized derivatives of 1alpha-hydroxy-5,6-trans-vitamin D3 was described. Ring-closing metathesis (RCM) of 1alpha-hydroxy-5,6-trans-vitamin D3 1-omega-alkenoates was a key-step. Hydride reduction of resulting lactones led to the new vitamin D3 analogues.
摘要
描述了一种合成1α-羟基-5,6-反式维生素D3的19-官能化衍生物的新途径。1α-羟基-5,6-反式维生素D3 1-ω-链烯酸酯的闭环复分解反应（RCM）是关键步骤。所得内酯的氢化还原反应产生了新的维生素D3类似物。
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