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DEAD盒蛋白p68/p72与非编码RNA类固醇受体激活剂SRA:不同生物学功能的兼性调节因子

The DEAD-box p68/p72 proteins and the noncoding RNA steroid receptor activator SRA: eclectic regulators of disparate biological functions.

作者信息

Caretti Giuseppina, Lei Elissa P, Sartorelli Vittorio

机构信息

Laboratory of Muscle Stem Cells and Gene Regulation, NIAMS, National Institutes of Health, Bethesda, Maryland 20892, USA.

出版信息

Cell Cycle. 2007 May 15;6(10):1172-6. doi: 10.4161/cc.6.10.4228. Epub 2007 May 3.

Abstract

p68 and p72 are RNA-binding proteins endowed with RNA helicase and RNA-protein complex remodeling activities. One of the RNAs associated with p68/p72 is the noncoding Steroid Receptors RNA Activator (SRA). Here we review recent findings on the cellular processes regulated by either p68/p72 alone or in combination with SRA and discuss the transcriptional events influenced by these molecules.

摘要

p68和p72是具有RNA解旋酶和RNA-蛋白质复合体重塑活性的RNA结合蛋白。与p68/p72相关的RNA之一是非编码类固醇受体RNA激活剂(SRA)。在此,我们综述了关于单独的p68/p72或与SRA联合调控的细胞过程的最新发现,并讨论了受这些分子影响的转录事件。

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