Caretti Giuseppina, Lei Elissa P, Sartorelli Vittorio
Laboratory of Muscle Stem Cells and Gene Regulation, NIAMS, National Institutes of Health, Bethesda, Maryland 20892, USA.
Cell Cycle. 2007 May 15;6(10):1172-6. doi: 10.4161/cc.6.10.4228. Epub 2007 May 3.
p68 and p72 are RNA-binding proteins endowed with RNA helicase and RNA-protein complex remodeling activities. One of the RNAs associated with p68/p72 is the noncoding Steroid Receptors RNA Activator (SRA). Here we review recent findings on the cellular processes regulated by either p68/p72 alone or in combination with SRA and discuss the transcriptional events influenced by these molecules.
p68和p72是具有RNA解旋酶和RNA-蛋白质复合体重塑活性的RNA结合蛋白。与p68/p72相关的RNA之一是非编码类固醇受体RNA激活剂(SRA)。在此,我们综述了关于单独的p68/p72或与SRA联合调控的细胞过程的最新发现,并讨论了受这些分子影响的转录事件。